The Use of Gonadotropin-Releasing Hormone Analogs beyond Precocious Puberty

Eugster, Erica A.

doi:10.1016/j.jpeds.2015.05.031

Cited by 9 publications

(3 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, others have failed to find any differences in self-image, self-esteem, or behavior in children with precocious puberty when compared to population norms [29, 30], Interestingly, one study even reported higher verbal IQ in a mixed group of girls with precocious puberty or PA compared with a control group with normally timed development [31]. Thus, this area has been identified as one that is sorely in need of additional research [32] and it is probably not a coincidence that literature reporting long-term outcomes of GnRHa therapy for CPP generally neglect psychological aspects of follow-up entirely [33–35]. Clearly, more information regarding this topic is essential.…”

Section: Discussionmentioning

confidence: 99%

One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment?

et al. 2017

View full text Add to dashboard Cite

Background: To determine whether psychological characteristics of girls with variations of early puberty and their mothers change over time and with treatment in girls with central precocious puberty (CPP). Methods: Girls with CPP, premature adrenarche (PA), and early normal puberty (ENP) completed psychological assessments at baseline and after 1 year along with their mothers. All girls with CPP were treated with GnRH analogs. Psychological effects of group and time were examined using 2 × 3 mixed ANOVAs. Results: Sixty-two subjects aged 7.5 ± 1.4 years (range 4.8–10.5) were enrolled, of whom 36 (15 with CPP, 8 with PA, and 13 with ENP) completed 1-year follow-up assessments. Psychological measures were normal in all girls. No significant group differences were found for any measure of girls’ psychological functioning at either time point. However, across all groups there was change over time with a decrease in perceived physical competence (p < 0.001) and an increase in perceived maternal acceptance (p = 0.001). Conclusion: No abnormalities in psychological functioning were found among girls with variations of early puberty, and all groups were in the normal range. Our results are largely reassuring regarding concerns of adverse psychological consequences of early puberty in girls.

show abstract

Section: Discussionmentioning

confidence: 99%

One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Once the benefit of GnRHas in improving final height in children with CPP was established, the potential to use these medications to impact height outside of CPP became an area of interest. Many studies have investigated the use of GnRHas in children with non-growth hormone deficient conditions with the goal of increasing adult height [3].…”

Section: Gonadotropin Releasing Hormone Analogs (Gnrhas)mentioning

confidence: 99%

Non-GH Agents and Novel Therapeutics in the Management of Short Stature

Saroufim

Eugster

2021

Indian J Pediatr

Self Cite

View full text Add to dashboard Cite

Short stature is one of the most common reasons for referral to pediatric endocrinologists. The vast majority of short children do not have growth hormone (GH) deficiency or another pathologic process that is interfering with normal growth. While GH has been approved in the US for several etiologies of non-GH deficient short stature, its high cost and need for daily injections represent barriers for many families. Alternative agents for the management of short stature include the use of gonadotropin releasing hormone analogs (GnRHas) to delay puberty, and aromatase inhibitors (AIs) in boys to postpone epiphyseal fusion. The results of studies employing GnRHas as either monotherapy or combined with GH are mixed, and there are a dearth of rigorously designed clinical trials that have followed patients to adult height. While AIs have been found to result in modest increases in adult height in some studies, important questions about their long-term safety exist. The C-type natriuretic peptide analog vosoritide is an experimental agent that is emerging as a potential treatment for a few specific conditions including achondroplasia although its efficacy in attenuating disproportionality is as yet unproven. While each of these therapeutic strategies holds promise, none are currently considered standard of care and several important questions remain. These include the impact of these interventions on quality of life as well as long-term outcomes.

show abstract

“…Pulsatile gonadotropin-releasing hormone (GnRH) is secreted into the hypophyseal portal blood system from hypothalamic neurons. GnRH activates its receptors on the anterior pituitary, which leads to the secretion of folliclestimulating hormone (FSH) and luteinizing hormone (LH) [8,9] . FSH and LH exert divergent effects and regulate essential reproductive processes, such as gametogenesis, steroidogenesis, and ovulation [10] , which are through binding to the FSH receptor (FSHR) and LH receptor (LHR) on the granulosa cell surface in the gonads, uterus, breasts, and other tissues, respectively [11,12] .…”

Section: Introductionmentioning

confidence: 99%

Koyunlarda Östrus İndüksiyonu Sonrası Ovaryum, Oviduct ve Endometriyumda Folikül Uyarıcı Hormon, Luteotropik Hormon, Östrojen ve Progesteron Reseptör Ekspresyonu

Yang¹,

Xiao-lei²,

Chen³

et al. 2019

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

Induction of estrus is an effective management tool for increasing the pregnancy rate in ewes, and there is a long estrus interval after lambing in spring in Small-tail Han ewe. In this study, norgestrel releasing intra-vaginal devices (PRID) and PRID + pregnant mare serum gonadotrophin (PMSG) were used for estrus induction in Small-tail Han ewe, and expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) and progesterone receptor (PGR) mRNA in the ovarial stroma, oviduct ampulla and endometrium was analyzed by quantitative real-time PCR. The results showed that the estrus-induction with PRID and PRID + PMSG almost had the same effects on increasing the percentage of animals in estrus and conception rate of the ewes, and the estrus-induction had no significant effect on the expression of LHR, ER and PGR mRNA in the oviduct ampulla, ovarial stroma and endometrium, and FSHR in the ovarial stroma and endometrium. Furthermore, the estrus-induction could significantly decrease the expression of FSHR mRNA in the ovine oviduct ampulla (P<0.05). Therefore, it was suggested that down-regulation of FSHR in the oviduct ampulla after estrus induction may be helpful for fertilization and early embryo development.

show abstract

The Use of Gonadotropin-Releasing Hormone Analogs beyond Precocious Puberty

Cited by 9 publications

References 55 publications

One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment?

One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment?

Non-GH Agents and Novel Therapeutics in the Management of Short Stature

Koyunlarda Östrus İndüksiyonu Sonrası Ovaryum, Oviduct ve Endometriyumda Folikül Uyarıcı Hormon, Luteotropik Hormon, Östrojen ve Progesteron Reseptör Ekspresyonu

Contact Info

Product

Resources

About