The use of human glutathione S‐transferase A₁ in the detection of cystic fibrosis liver disease

Abstract

Serum hGST A1 measurement increases the sensitivity of detecting hepatic abnormalities when included with clinical and ultrasound evaluation although, in some cases with advanced liver disease, serum hGST A1 may be normal. Conventional liver enzyme tests add little information in the detection of CF liver disease.

Serum markers of hepatic fibrogenesis in cystic fibrosis liver disease

“…However, no stratification was undertaken with severity of fibrosis. Two studies have suggested that human glutathione S transferase A1 (GSTA) was superior to conventional transaminases and comparable to ultrasonography in detecting liver disease, but its utility for detecting hepatic fibrosis was not determined as no biopsies were undertaken [24,25]. Serum PIIIP and PH were studied in 44 children with CF, 26 with suggestion of liver disease by clinical and ultrasound abnormalities [21].…”