The Use of Hyaluronidase With Local Anesthetic Agents in Surgery and Dentistry

Kirby, Charles K.; Eckenhoff, James E.; Looby, John P.

doi:10.1111/j.1749-6632.1950.tb54020.x

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…Ligation of the bile duct and of the ampulla, where the bile duct ends in the duodenum, prevented leakage of the tracer from the pancreas. The hyaluronidase and collagenase were added to the HRP solution to overcome perineural barriers like connective tissue components and basal laminae in order to obtain optimal tracer uptake by nerve terminals [16,19]. Comparison with preliminary experiments in which these enzymes were not added to the tracer solution showed that the enzymes mentioned greatly improve the density of the labeling and allow the positive detection of approximately 20% more cells.…”

Section: Methodsmentioning

confidence: 99%

Preganglionic innervation of the pancreas islet cells in the rat

Luiten

Horst

Koopmans

et al. 1984

Journal of the Autonomic Nervous System

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Section: Methodsmentioning

confidence: 99%

Preganglionic innervation of the pancreas islet cells in the rat

Luiten

Horst

Koopmans

et al. 1984

Journal of the Autonomic Nervous System

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“…As an adjuvant in infiltration and nerve block anesthesia, hyaluronidase wrEs found useful in increasing the area and depth; it decreased the duration of anesthesia (199)(200)(201)(202). I n caudal blocks and in nerve blocks in other parts of the body, little advantage from the use of hyaluronidase was reported by Moore, while the usefulness in infiltration anesthesia was confirmed (202).…”

Section: Clinical Applications Of Hyaluronidasementioning

confidence: 99%

Hyaluronidases

Meyer¹,

Rapport²

1952

Advances in Enzymology - And Related Areas of Molecular Biology

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“…In some studies, it was found that the duration of anaesthesia when epinephrine was added to local anaesthetic agents was roughly the same with and without hyaluronidase. Epinephrine seems to increase the spreading effect of hyaluronidase 16 …”

Section: Discussionmentioning

confidence: 95%

“…Epinephrine seems to increase the spreading effect of hyaluronidase. 16 This study was a split-mouth study and the limitation of this study was that identical bilateral extractions were not performed. Some study shows that hyaluronidase increases the systemic absorption of LA, but according to a study where local anaesthesia was mixed with hyaluronidase to check for the peak plasma concentration they found that the addition of hyaluronidase had no clinically important effect on systemic absorption of lignocaine.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions

Lunkad,

Shah,

Rudagi

et al. 2024

Oral Surgery

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PurposeTo evaluate and compare the efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions.Patients and MethodsThis was the split‐mouth study conducted on 26 patients requiring bilateral mandibular teeth extraction. All the patients were assigned randomly to one of the two groups: (i) 2% lignocaine HCl + 1:2,00,000 adrenaline + hyaluronidase (75 IU) solution will be administered on one side which is the experimental side and (ii) 2% lignocaine HCl + 1:2,00,000 adrenaline solution on the other side is control side. In the first session, the patients randomly received the inferior alveolar nerve block with or without hyaluronidase in one side of the oral cavity. One week later, the same patient received the other technique which was not received in the first session. We also evaluated the onset, duration and need of any supplementary anaesthesia in both the groups.ResultsComparison of VAS score in the control group (2.73 ± 0.724) and experimental group (3 ± 0.693) showed statistically insignificant results (p = 0.177). Whereas the onset of local anaesthesia showed a statistically significant difference between the two groups (p < 0.001) mean of control group (2.73 ± 0.47) and experimental group (1.15 ± 0.23). Comparison of duration of anaesthesia showed a statistically significant difference (p < 0.001) with the mean duration of the experimental group being higher (106 ± 7.94) than the control group (86.27 ± 3.90). Comparison for the need for supplementary anaesthesia showed no statistically significant difference between the two groups.ConclusionWe conclude that if hyaluronidase is used, better blocks with smaller volumes are produced. LAs with hyaluronidase have been shown to improve the quality and effectiveness of anaesthetic blocks and shorten the time it takes for anaesthesia to begin, accelerate the onset of akinesia and lessen the need for additional anaesthesia. It also increases the duration of anaesthesia.

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The Use of Hyaluronidase With Local Anesthetic Agents in Surgery and Dentistry

Cited by 10 publications

References 8 publications

Preganglionic innervation of the pancreas islet cells in the rat

Preganglionic innervation of the pancreas islet cells in the rat

Hyaluronidases

Comparative evaluation of efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions

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