The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats

Silva, R.V.; Camilli, José Ângelo; Bertran, Celso Aparecido; Moreira, Ney Henrique

doi:10.1016/j.ijom.2004.06.005

Cited by 78 publications

(73 citation statements)

References 23 publications

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“…Current hard tissue engineering applications include bone repair, bone augmentation, coating of metal implants, and as filler material for both bone and teeth. [9][10][11] Unfortunately, due to its low mechanical strength, the use of pure HAP ceramics is restricted to low load bearing clinical applications. In some cases, combining HAP with other materials, such as polymers and/or glasses to form a composite, can alleviate these deficiencies.…”

Section: Introductionmentioning

confidence: 99%

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Poinern¹,

Brundavanam²,

Le³

et al. 2011

IJN

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Hydroxyapatite (HAP) is a widely used biocompatible ceramic in many biomedical applications and devices. Currently nanometer-scale forms of HAP are being intensely investigated due to their close similarity to the inorganic mineral component of the natural bone matrix. In this study nano-HAP was prepared via a wet precipitation method using Ca(NO 3 ) 2 and KH 2 PO 4 as the main reactants and NH 4 OH as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH was maintained at 9 during the synthesis process. The influence of the thermal treatment was investigated by using two thermal treatment processes to produce ultrafine nano-HAP powders. In the first heat treatment, a conventional radiant tube furnace was used to produce nano-particles with an average size of approximately 30 nm in diameter, while the second thermal treatment used a microwave-based technique to produce particles with an average diameter of 36 nm. The crystalline structure and morphology of all nanoparticle powders produced were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). Both thermal techniques effectively produced ultrafine powders with similar crystalline structure, morphology and particle sizes.

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Section: Introductionmentioning

confidence: 99%

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Poinern¹,

Brundavanam²,

Le³

et al. 2011

IJN

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“…Such capabilities have made HAP an ideal candidate for orthopaedic and dental implants or part thereof. Synthetic HAP has been used widely for the repair of hard tissues and its common uses are bone repair, bone augmentation as well as coating of implants or acting as fillers in bone or teeth [9][10][11]. However the low mechanical strength of normal HAP ceramics restricts its use mainly to conditions of low load bearing applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

Poinern

Brundavanam

Mondinos

et al. 2009

Ultrasonics Sonochemistry

155

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Nanostructured hydroxyapatite (HAP) was prepared by a wet precipitation method using Ca(NO 3 ) and KH 2 PO 4 as the main material and NH 3 as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH maintained at a minimum of 9. The temperature conditions and ultrasound influences were investigated using X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The results showed that Nano-HAP can be obtained by this method and the particles were achieved to around 30nm.

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“…Currently, several CPC with varying compositions of the powder and liquid components are commercially available and many more are in experimental stages (4)(5)(6)(7)(8)(9)(10).Unlike the calcium phosphate bioceramics in granules or pre-shaped form, CPC has the major advantage of being able to readily adapt to the shape of the bone defect, rapidly integrate into the bone structure and be transformed into new bone (8)(9)(10) by the cellular action of bone cells (osteoclasts and osteoblasts) responsible for the local bone remodelling (11)(12)(13)(14). However, in spite of these optimal properties, CPCs have limitations due to their poor mechanical properties and low in vivo biodegradation.…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical–mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates

et al. 2007

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The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats

Cited by 78 publications

References 23 publications

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

Physico-chemical–mechanical and in vitro biological properties of calcium phosphate cements with doped amorphous calcium phosphates

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