The Use ofHibiscus esculentus(Okra) Gum in Sustaining the Release of Propranolol Hydrochloride in a Solid Oral Dosage Form

Abstract

The effectiveness of Okra gum in sustaining the release of propranolol hydrochloride in a tablet was studied. Okra gum was extracted from the pods of Hibiscus esculentus using acetone as a drying agent. Dried Okra gum was made into powder form and its physical and chemical characteristics such as solubility, pH, moisture content, viscosity, morphology study using SEM, infrared study using FTIR, crystallinity study using XRD, and thermal study using DSC and TGA were carried out. The powder was used in the preparation of tablet using granulation and compression methods. Propranolol hydrochloride was used as a model drug and the activity of Okra gum as a binder was compared by preparing tablets using a synthetic and a semisynthetic binder which are hydroxylmethylpropyl cellulose (HPMC) and sodium alginate, respectively. Evaluation of drug release kinetics that was attained from dissolution studies showed that Okra gum retarded the release up to 24 hours and exhibited the longest release as compared to HPMC and sodium alginate. The tensile and crushing strength of tablets was also evaluated by conducting hardness and friability tests. Okra gum was observed to produce tablets with the highest hardness value and lowest friability. Hence, Okra gum was testified as an effective adjuvant to produce favourable sustained release tablets with strong tensile and crushing strength.

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

“…Foliate is a vital nutrient that increases the growth and development of the fetus' brain. The high quantity of folic acid within okra performs a huge role within the neural tube formation of the fetus through the fourth to the 12th week of pregnancy (Zaharuddin et al, 2014). Okra is used to improves heart health.…”

Functional properties of Okra Abelmoschus esculentus L. (Moench): traditional claims and scientific evidences

“…Lim, 2012;Marwat et al, 2011Marwat et al, . 2012Zaharuddin, Noordin, & Kadivar, 2014). Besides this plant is also the treasure house of polyphenolic compounds.…”

“…Recently this same research group (Sharma, Kulkarni, Sharma, Bhatnagar, & Kumar, 2013b) have prepared and evaluated of mucoadhesive microspheres, using okra polysaccharide as a novel carrier for safe and effective delivery of rizatriptan benzoate into nasal cavity. It is also used to study the sustaining release of drug (Zaharuddin et al, 2014). Besides colon specific drug delivery studies also been carried out (Rajkumari, Sarma, Ilango, Devi, & Rajak, 2012).…”

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“…It is also used to study the sustaining release of drug 75 . Besides colon specific drug delivery studies also been carried out 76 .…”