The Use of I131 Triolein in the Study of Absorptive Disorders in Man

Assessment of the Radiotriolein Test in Steatorrhoea

“…Most authors favour the suggestion that this occurs in the mucosal cells of the alimentary tract, and this is supported by the in vitro tests of Balint et al (1960), in which appreciable liberation of free 131l occurred when RIT was incubated in extracts of intestinal mucosa. Similar experiments by the same workers, and by Beres et al (1957), failed to detect free 1311 when RIT was incubated in a variety of intestinal secretions; however, their periods of incubation were relatively short. The use of an anion exchange resin to determine free 1311 in radio-iodinated lipids offered a simple means of studying the behaviour of the RIT bond over a longer period of time.…”

Use of labelled triolein, vitamin A, and D-xylose in the diagnosis of malabsorption

“…The inverse relationship between faecal and blood radioactivity noted by Ruffin et al (1956) was confirmed. The failure of correlation between faecal fat losses and circulating radioactivity noted by McKenna, Bourne, and Matzko (1957), Beres, Wenger, and Kirsner (1957), Grossman and Jordan (1958), Mohamed and Hume (1959), Pimparkar et al (1960), and Rufin et al (1961 was also noted in this study, and attributed to the mechanisms already held to be responsible for the falsely low faecal radioactivity in these patients. Analysis of the other tolerance tests shows that abnormal results are found in severe malabsorption, but a similar failure to produce a normal increase in blood levels of vitamin A or urinary excretion of xylose may be found in patients with apparently normal alimentary tracts.…”

Serum studies in man after administration of vitamin A acetate and vitamin A alcohol: II In subjects suffering from disturbances of absorption and digestion

“…It has already been pointed out that serum tolerance tests depend on factors other than absorption alone, so it is to be expected that there would be closer correlation between one serum tolerance test and another rather than between a serum tolerance test and a balance test. DISCUSSION Because of the variation in results obtained with vitamin A absorption tests in both normals and abnormals noted by some-authors (Mendeloff, 1954;Hillman and Becker, 1957) this test has been less frequently used than other absorption tests, such as fat balance or the more recently introduced 1131 tagged fats, both of which have been much used (Shingleton et al, 1957;Beres, Wenger, and Kirsner, 1957;Duffy and Turner, 1958). Our experience with the vitamin A tests has led us to conclude that it is a satisfactory test and may have certain advantages over other tests for the following reasons:-It is less laborious than the commonly used fat balance test, both for patients and medical personnel.…”