The Use of Immunoglobulin Therapy for Patients With Primary Immune Deficiency: An Evidence-Based Practice Guideline

Shehata, Nadine; Palda, Valerie A.; Bowen, Tom; Haddad, Élie; Issekutz, Thomas B.; Mazer, Bruce; Schellenberg, Robert; Warrington, Richard; Easton, David; Anderson, David R.; Hume, Heather

doi:10.1016/j.tmrv.2009.09.011

Cited by 103 publications

(93 citation statements)

References 91 publications

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Section: Canadian Perspectivementioning

confidence: 99%

“…On the other hand, because of the availability of scig, igrt need no longer be given intravenously; in fact, scig is now the mainstay of administration in patients with a genetic basis for hgg 57 . In such patients, scig is considered equally as efficacious as ivig with respect to a reduction in the frequency and severity of respiratory tract infections 57 . Additionally, scig achieves steady serum levels, avoiding the peaks and troughs associated with ivig administration; whether that lesser variation is associated with fewer periods at risk for infection remains plausible, but unproven 34,45 .…”

Section: Canadian Perspectivementioning

confidence: 99%

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A Canadian Perspective on the Use of Immunoglobulin Therapy to Reduce Infectious Complications in Chronic Lymphocytic Leukemia

Lachance

Christofides²,

Lee³

et al. 2016

Current Oncology

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Infections are a major cause of morbidity and mortality in patients with chronic lymphocytic leukemia (cll), who typically have increased susceptibility because of hypogammaglobulinemia (hgg) related to their disease and its treatment. Immunoglobulin replacement therapy (igrt) has been shown to reduce the frequency of bacterial infections and associated hospitalizations in patients with hgg or a history of infection, or both. However, use of igrt in cll is contentious. Studies examining such treatment were conducted largely before the use of newer chemoimmunotherapies, which can extend lifespan, but do not correct the hgg inherent to the disease. Thus, the utility of igrt has to be re-evaluated in the current setting. Here, we discuss the evidence for the use of igrt in cll and provide a practical approach to its use in the prevention and management of infections.

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Section: Canadian Perspectivementioning

confidence: 99%

Section: Canadian Perspectivementioning

confidence: 99%

A Canadian Perspective on the Use of Immunoglobulin Therapy to Reduce Infectious Complications in Chronic Lymphocytic Leukemia

Lachance

Christofides²,

Lee³

et al. 2016

Current Oncology

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“…However, its use should take into account several aspects related to efficacy and safety. 8 Preparations mainly contain IgG at sufficient concentrations to protect against sepsis and to reduce recurrent or chronic pulmonary infections, reflecting the immunologic memory of the donors. 9 GRT has proved to be highly effective by significantly reducing the incidence of acute respiratory infections, especially pneumonias, and reducing the risk for chronic lung disease.…”

Section: Gammaglobulin Replacement Gammaglobulin Replacementmentioning

confidence: 99%

Gammaglobulin for primary immunodeficiency: when should it be used?

Roxo-Junior

2014

Medicina (Ribeirão Preto)

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Antibodies are an essential component of the adaptative immune response and hold long-term memory of the immunological experiences throughout life. Antibody defects represent approximately half of the well-known primary immunodeficiencies requiring gammaglobulin replacement therapy. On the other hand this therapy can be used for some diseases that do not belong to this group, like hyper IgM syndrome, immunodeficiency with thymoma and severe combined immunodeficiency. This therapy is a safe procedure and induces dramatic improvement in the clinical outcome of patients, reducing the risks of death and complications.

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“…Components of blood like platelets, plasma and immunoglobulin are also obtained through centrifugation and given to patients with blood disorders and immune deficiency [2], [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Blood Donation And Misconceptions- A Nationwide Survey In Dental Hospitals Of Pakistan

Hashmi

Tanwir

Rai³

et al. 2017

JHOR

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, Data was collected from eight dental hospitals in four provinces of Pakistan. Attendants of the patients admitted in the surgical ward with age more than 16 years were included. Knowledge and practices of the participants were evaluated through a selfadministered questionnaire .Ethical consent was obtained from the ethical committee or concerned authority of all eight hospitals. Results:Response rate was 84 %. In total 55% male and 45 % female participated with 15.5% of the total sample population was under the age of 20 years. The age group with the maximum number of participant was between 20 to 39 years of age. 26% and 22.5% of the males and female participants respectively had knowledge . About blood donation, lesser percentage of attendants, 7.2% of the males and 4.6% declared that they had donated blood in the past. Based on education levels, it was highest among graduates (3.5%) and less in primary educated (2.2%) and uneducated respondents was 0.7%. 18% of the males and 17% females asserted that they hold some kind of fear of blood donation. Conclusion:The population is not adequately knowledgeable regarding blood donation. There is a need for proper campaign to educate masses at national level within Pakistan to promote more people to become regular volunteers.

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The Use of Immunoglobulin Therapy for Patients With Primary Immune Deficiency: An Evidence-Based Practice Guideline

Cited by 103 publications

References 91 publications

A Canadian Perspective on the Use of Immunoglobulin Therapy to Reduce Infectious Complications in Chronic Lymphocytic Leukemia

A Canadian Perspective on the Use of Immunoglobulin Therapy to Reduce Infectious Complications in Chronic Lymphocytic Leukemia

Gammaglobulin for primary immunodeficiency: when should it be used?

Blood Donation And Misconceptions- A Nationwide Survey In Dental Hospitals Of Pakistan

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