Adopting teaching and learning approaches focused on 21st-century competencies necessitates creative solutions that span traditional classroom settings and the internet world in the quickly changing educational landscape. To cultivate these competencies, this chapter explores the transformative potential of novel learning spaces and blended learning approaches. This theoretical review uses secondary data as its main source and incorporates the most recent methodological and meta-analytical literature evaluations to cross-validate its conclusions. By merging flexible and adaptable physical and virtual environments with advanced technological tools, this chapter offers practical strategies for educators and policymakers to enhance student engagement and promote critical thinking, creativity, collaboration, and digital literacy. It aims to empower educational institutions to embrace and sustain these innovative approaches, ensuring all students acquire the skills necessary to thrive in a digital and interconnected world.