The use of insulin-like growth factor 1 improved the parameters of the seminogram in a patient with severe oligoasthenoteratozoospermia

Rodríguez, José Arturo Mora; Porchia, Leonardo M.; Camargo, Felipe N.; López-Bayghen, Esther

doi:10.1177/2050313x19834154

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…In fact, testicular IGF‐I expression is controlled by FSH and LH, in the Leydig and Sertoli cells, respectively (Singh, 2019). Therefore, oligoasthenoteratozoospermic men, treated with IGF‐I, improved the semen quality increasing sperm concentration, progressive motility and volume (Rodríguez et al, 2019), since the IGF‐I is considered an antioxidant factor, which prevent the action of reactive oxygen species on spermatozoa (Binsila et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Seminal plasma insulin‐like growth factor I and total protein concentration in peripubertal period of the Gyr bulls

Souza¹,

Martins

Emerick

et al. 2021

Reprod Domestic Animals

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This study aimed to evaluate the correlation of seminal plasma IGF‐I and total proteins from peripubertal bulls with semen characteristics and onset of puberty. Sixteen dairy Gyr bulls were separated into early (n = 8) and regular (n = 8) groups, according to the onset of puberty. Semen was monthly collected by electroejaculation from 14 to 26 months of age, and the onset of puberty was retrospectively determined (17.0 ± 1.6 and 19.2 ± 1.5 months, to early and regular group, respectively). Five time points were evaluated (day −60, day −30, day 0, day 30 and day 60 days of puberty), being day 0 considered as beginning of puberty. Scrotal circumference and body weight were also assessed. Semen characteristics were evaluated, the seminal plasma was separated by centrifugation and total protein and IGF‐I concentrations were determined. There was no difference between groups to concentration of the seminal plasma total proteins, but we found an interaction between group and age. Seminal plasma IGF‐I concentrations were not different between early and regular groups; thus, the data were combined for analysis. Combined IGF‐I concentrations were positively correlated with sperm motility and concentration, age, body weight and scrotal circumference. Negative correlation was found between IGF‐I concentration and total sperm defects. Increased IGF‐I was observed in day −30 and day 0 of puberty in early and regular groups, respectively. Seminal plasma total proteins are involved in peripubertal modifications and IGF‐I from Zebus dairy bulls can influence the seminal characteristics and the growth factor increase occurs concomitantly with body growth but cannot be used to define puberty bulls earlier.

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Section: Discussionmentioning

confidence: 99%

Seminal plasma insulin‐like growth factor I and total protein concentration in peripubertal period of the Gyr bulls

Souza¹,

Martins

Emerick

et al. 2021

Reprod Domestic Animals

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“…IGF-I, a potent mitogenic and metabolic substance, is an important regulator of reproductive functions [ 27 ]. IGF-I in seminal plasma is primarily produced by the testicular and epididymal organs [ 28 ]. However, most local tissue IGF does not exist as free molecules [ 29 ] but forms a ternary complex that consists of IGF-I, IGFBP-3, and acid-labile subunit with a molecular weight of 150 kDa [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

A 150 kDa Protein Derived from Bull Seminal Plasma Extended the Survival Time of Kacang Goat Sperm Stored at 5°C

Susilowati

Mustofa

Wurlina

et al. 2021

Veterinary Medicine International

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Artificial insemination has proven to be an effective method for increasing population size and genetic quality of Kacang goats. However, innovation is required to maintain the quality of Kacang goat semen in storage. This study aimed to examine the effects of supplementing the 150 kDa protein assumed as IGF-I complex derived from bull seminal plasma in skim milk-egg yolk extender on the quality of Kacang goat sperm stored at 5°C. Twelve ejaculates collected from three Kacang goats were divided into three groups. In the control group (T0), the ejaculates were extended with skim milk-egg yolk only. In the treatment groups (T1 and T2), the ejaculates were extended with skim milk-egg yolk supplemented with the IGF-I complex protein at 12 μg and 24 μg/100 mL, respectively. The extended semen was stored at 5°C, and the viability, motility, intactness of the plasma membrane, malondialdehyde concentration, and apoptotic sperm percentage were evaluated daily for five days. The results showed that the T1 was the most effective treatment for maintaining Kacang goat semen at a quality acceptable for artificial insemination over five days of storage at 5°C. However, the T0 and T2 groups retained acceptable qualities for only three days at 5°C. It could be concluded that supplementation of 12 μg of the 150 kDa protein derived from bull seminal plasma per 100 mL extender successfully extended the life span of Kacang goat sperm for five days.

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“…Asherman syndrome is an acquired disorder 76, and fallopian tube obstruction occurs due to the blockage in women's fallopian tube. All these symptoms are the main causes of infertility in women worldwide 77 .…”

Section: Mesenchymal Stem Cells In Female Infertilitymentioning

confidence: 99%

“…Astrogliosis happens in AD, and also the level of astrogliosis changes is connected with cognitive problems. Astrocytes reveal a number of receptors for chemokines and also inflammatory cytokines consisting of those like IL-1β and also TNF-α 77 . microglia to produce insulin-like growth factor (IGF)-1 80 .…”

Section: Fig 2: Effects Of Mscs On Different Immune Cellsmentioning

confidence: 99%

Untitled

2022

IJPSR

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Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self-restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to promote functional recovery in many neurological disorders. Neuroinflammation is a pathological feature of neurodegenerative diseases, which is also indicated to mediate neuronal damage and deteriorate the backward accumulation of Aβ in Alzheimer's disease. The mechanism for MSC-based therapy in Alzheimer's disease that MSCs regulate neuroinflammation by microglia activation; this will reduce pathological features such as tau hyperphosphorylation and Aβ deposits and save the spatial learning and memory deficits and their multipotentiality and secretome, based on these findings include cell therapy methods for Parkinson disease mainly focused on the ability of stem cells to differentiate into Dopaminergic neurons producing cells that will replace diseased Dopaminergic neurons. MSC-based therapeutics have been suggested for osteoarthritis. MSCs were mostly found in a thin layer of connective tissue called periosteum, lungs, milk teeth, tendon, synovial stratum, cancellous bone, adipose tissue, tendon, lung, and other tissues. MSCs associated with immune cells and have immunomodulatory effects. Moreover, the RAP1/NFkb signalling pathway controls MSC paracrine activity, which seems to be linked with Female infertility. This review will assist you in understanding many aspects of MSC and its molecular role and therapeutic applications.

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The use of insulin-like growth factor 1 improved the parameters of the seminogram in a patient with severe oligoasthenoteratozoospermia

Cited by 8 publications

References 13 publications

Seminal plasma insulin‐like growth factor I and total protein concentration in peripubertal period of the Gyr bulls

Seminal plasma insulin‐like growth factor I and total protein concentration in peripubertal period of the Gyr bulls

A 150 kDa Protein Derived from Bull Seminal Plasma Extended the Survival Time of Kacang Goat Sperm Stored at 5°C

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