The use of integrated behavioural z-scoring in behavioural neuroscience – A perspective article

Kraeuter, Ann Katrin

doi:10.1016/j.jneumeth.2022.109751

Cited by 8 publications

(3 citation statements)

References 75 publications

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“…[13,14,21]. Manual lateralization was also approached from the perspective of neuroscience, which studies the connection between the functionality of the brain and the biological aspects of human performance and behavior [80][81][82]. Recent studies have demonstrated that there are close links between motor and sensory functions, which generate predictions for the formation of new motor experiences with different stimuli and in different training conditions [83,84].…”

Section: Discussionmentioning

confidence: 99%

Identifying the Level of Symmetrization of Reaction Time According to Manual Lateralization between Team Sports Athletes, Individual Sports Athletes, and Non-Athletes

Badau,

Joksimović

et al. 2023

Symmetry

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The present study aimed to investigate the impact of practicing sports activities on manual skills, focused on reaction time depending on manual laterality. The objectives of the study were to identify the differences in improving simple, optional, and cognitive reaction times in the manual executions of student athletes who practice team sports involving the manual handling of the ball (volleyball, basketball, handball) in comparison with student athletes who practice individual sports and with non-athletic students; to identify the differences regarding the reaction time of the right- and left-handed executions depending on the manual lateralization of the subjects (right- and left-handedness) between the three experimental samples: team sports group (TSG), individual sports group (ISG), and the group of non-athletes (NAG) through the use of computer tests. The study included 335 subjects who were divided into three groups: TSG with 102 subjects, ISG with 112 subjects, and NAG with 121 subjects. The subjects of the study were given five computer tests to evaluate three types of reaction time: simple reaction time (Start/Stop Test), choice reaction time (Check Boxes Test, Hit-the-dot Test), and time of cognitive reaction (Trail making Test part A and B). The results were analyzed regarding right- and left-handedness, as well as the execution hand (right hand or left hand) in solving the tests. The results of the study highlighted significant statistical differences between the three groups: TSG, ISG, and NAG. The best results were recorded by TSG in all tests, and the lowest by NAG. Statistically significant differences were also recorded between the executions with the dominant hand compared to the executions with the non-dominant hand in relation to right- and left-handedness. The study highlighted that the smallest differences in all the study groups were recorded in the simple reaction time test, where the differences between the right-handed and left-handed executions were the lowest, reflecting the best level of symmetrization of the motor executions.

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Section: Discussionmentioning

confidence: 99%

Identifying the Level of Symmetrization of Reaction Time According to Manual Lateralization between Team Sports Athletes, Individual Sports Athletes, and Non-Athletes

Badau,

Joksimović

et al. 2023

Symmetry

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“…To further affirm our behavioural findings, we calculated an integrated anxiety- Z-score from our open field, elevated plus maze and nest building output (Guilloux et al, 2011; Kraeuter, 2023). As expected, the Z-score result reflected the behavioural variation we observed amongst mice within each stress group and did not show a consistent trend in either direction for an increase (> 0) or decrease (< 0) in anxiety across all 3 behavioural tests.…”

Section: Discussionmentioning

confidence: 93%

High fat diet consumption and social instability stress impair stress adaptation and maternal care in C57Bl/6 mice

Bucknor,

Gururajan,

Dale

et al. 2024

Preprint

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Poor maternal diet and psychosocial stress represent two environmental factors that can significantly impact maternal health during pregnancy. While various mouse models have been developed to study the relationship between maternal health and offspring development, few incorporate multiple sources of stress that mirror the complexity of human experiences. Maternal high-fat diet (HF) models in rodents are well-established, whereas maternal psychosocial stress models are still emerging. The social instability stress (SIS) paradigm, serves as a chronic and unpredictable form of social stress. To evaluate the combined effects of a poor maternal diet and social stress on maternal health and behaviour, we developed a novel maternal stress model in adult female C57Bl/6 mice. We observed that all HF+ mice demonstrated rapid weight gain, elevated fasting blood glucose levels and impaired glucose tolerance independent of the presence (+) or absence (-) of SIS. Behavioural testing revealed anxiety-like behaviors remained across all groups prior to pregnancy. However, we did observe a trend of poorer nest quality among all HF+ mice compared to HF- mice following nest building testing. Unlike the other HF+ and HF- stress groups, which exhibited significantly reduced plasma ACTH and corticosterone levels following SIS exposure, we did not observe this reduction in HF+/SIS+ females. In addition, HF+/SIS+ females demonstrated significant postpartum maternal neglect, resulting in fewer numbers of live offspring. These findings suggest that prolonged maternal HF diet consumption, coupled with SIS, places a significant burden on the maternal stress response system, resulting in reduced parental investment and negative postpartum behaviour towards offspring.

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“…To gain perspective on overall affective dysregulation, we conducted an exploratory analysis on the computed composite symptom score. Such methodology has been utilized in a variety of similar contexts and has been shown to yield robust measures across complementary tasks [67][68][69]. Behavioral assessments were reverse-scored as needed, such that higher scores represent higher symptoms.…”

Section: Discussionmentioning

confidence: 99%

Chronic Stress Exacerbates Hyperglycemia-Induced Affective Symptoms in Male Mice

McCready,

Gilley,

Kusumo

et al. 2023

Neuroimmunomodulation

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Introduction: Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression and anxiety. The mechanisms underlying stress-induced affective dysregulation are likely distinct from that induced by diabetes. A direct comparison between stress- and hyperglycemia-induced affective dysregulation could provide insight into distinct mechanistic targets for depression/anxiety associated with these different conditions. Methods: To this end, the present study used male C57BL/6J mice to compare the independent and combined behavioral and neuroinflammatory effects of two models: (1) unpredictable chronic mild stress and (2) pharmacologically induced hyperglycemia. Results: Streptozotocin-induced hyperglycemia was associated with a set of behavioral changes reflective of the neurovegetative symptoms of depression (i.e., reduced open field activity, reduced grooming, increase immobility in the forced swim task, and decreased marble burying), increased hippocampal Bdnf and Tnf expression, and elevations in frontal cortex Il1b expression. Our chronic stress protocol produced alterations in anxiety-like behavior and decreased frontal cortex Il1b expression. Discussion: While the combination of chronic stress and hyperglycemia produced limited additive effects, their combination exacerbated total symptom burden. Overall, the data indicate that stress and hyperglycemia induce different symptom profiles via distinct mechanisms.

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The use of integrated behavioural z-scoring in behavioural neuroscience – A perspective article

Cited by 8 publications

References 75 publications

Identifying the Level of Symmetrization of Reaction Time According to Manual Lateralization between Team Sports Athletes, Individual Sports Athletes, and Non-Athletes

Identifying the Level of Symmetrization of Reaction Time According to Manual Lateralization between Team Sports Athletes, Individual Sports Athletes, and Non-Athletes

High fat diet consumption and social instability stress impair stress adaptation and maternal care in C57Bl/6 mice

Chronic Stress Exacerbates Hyperglycemia-Induced Affective Symptoms in Male Mice

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