The use of intraoral ultrasound in the characterization of minor salivary gland malignancy: report of two cases

Sengupta, Anita; Brown, Jackie; Rudralingam, Meena

doi:10.1259/dmfr.20150354

Cited by 9 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first line of imaging when suspecting neoplastic growth in a major salivary gland is ultrasound [ 61 ], which is a noninvasive technique that can help identify the nature of any lump, its approximate borders, and its contents [ 62 ]. Additionally, ultrasound can be used in some diagnostic or interventional procedures as a 3D guidance when performing fine needle aspiration biopsy (FNA) or cytology screening for SACC as an initial biopsy technique.…”

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

View full text Add to dashboard Cite

Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2. Lesions of SACC are often insidious and slow-growing, and symptoms such as pain and altered sensation are frequently associated with advanced stages of the disease. Salivary adenoid cystic carcinoma is characterized by perineural invasion (PNI), a distinctive feature that potentially plays a significant role in the tumor’s relapse and recurrence, which is approximately 50%. The disease is not prevalent, and its etiopathogenesis is poorly understood, although several genetic patterns and biomarkers have been linked to its initiation and/or progression. The discovery of these mutations and biomarkers has encouraged several clinical studies to use therapeutic agents to target the specific receptors on the cancer cells to potentially prevent further proliferation of the tumor cells and metastasis of the disease. Diagnosis of SACC is often challenging and frequently requires a combination of clinical examination, imaging, and histopathology. Management of SACC is primarily surgical excision, while radiotherapy has shown to be effective in improving local control in cases with microscopic residual disease. However, treatment of recurrent or metastatic tumors by radiotherapy with or without chemotherapy has so far shown limited success. The aim of this thesis is to provide an update of literature on SACC with a particular focus on the latest management approaches and future trends.

show abstract

Section: Resultsmentioning

confidence: 99%

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Saleh

Ukwas

2023

International Journal of Otolaryngology

View full text Add to dashboard Cite

show abstract

“…On the other hand, the pre-surgical evaluation of minor salivary gland by US alone is more difficult due to the location of minor salivary gland. For tumor located within oral cavity, we can use intra-oral US [ 39 ]. For tumor outsides oral cavity or for more detail information, MRI or CT is more suitable than US [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors

Cheng

Chang

et al. 2022

Diagnostics

View full text Add to dashboard Cite

We aimed to validate the diagnostic accuracy of a novel sonographic scoring model and compare it with other methods in the evaluation of malignant major salivary gland tumors. We enrolled 138 patients who received neck ultrasound (US) with fine needle aspiration (FNA) and further operations or core needle biopsies for major salivary gland tumors from June 2015 to October 2021. The sonographic scoring model was presented as 2.08 × (vague boundary) + 1.75 × (regional lymphadenopathy) + 1.18 × (irregular or speculated shape) + 1.45 × (absence of posterior acoustic enhancement) + 2.4 × (calcification). We compared the diagnostic accuracy of the sonographic scoring model with shear wave elastography (SWE), real-time elastography (RTE), and US-FNA cytology for differentiating between benign and malignant lesions. The sensitivity, specificity, and accuracy were 58%, 89%, and 85% for the sonographic scoring model, 74%, 62%, and 64% for the SD of SWE with optimal cutoff value of 31.5 kPa, 69%, 70%, and 70% for the 4-point scoring system of RTE, and 74%, 93%, and 91% for US-FNA cytology, respectively. The sonographic scoring model is feasible as assistance in the evaluation of major salivary gland tumors. US-FNA cytology remains the tool of choice in diagnosing malignant salivary gland tumors.

show abstract

“…Ultrasonography (US) is a diagnostic procedure that uses sound waves, emitted by piezoelectric crystals, and their echoes are capable of producing images of anatomical structures [70]. Ultrasound is routinely used in various branches of medicine, such as gynecology, gastroenterology, cardiology, and angiology; with regard to the head and neck region, it is used to detect structural abnormalities and/or tumors of the salivary glands [71,72]. The use of this technique in the oral cavity is less frequent but, in any case, different uses have been reported in the literature: from the study of periodontal and peri-implant tissues to the clinical and surgical characterization of benign and malignant lesions of the oral mucosa [73][74][75].…”

Section: High-frequency Ultrasound (Us)mentioning

confidence: 99%

Noninvasive Imaging Methods to Improve the Diagnosis of Oral Carcinoma and Its Precursors: State of the Art and Proposal of a Three-Step Diagnostic Process

Romano

Stasio

Petruzzi

et al. 2021

Cancers

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is the most prevalent form of cancer of lips and oral cavity, and its diagnostic delay, caused by misdiagnosis at the early stages, is responsible for high mortality ratios. Biopsy and histopathological assessment are the gold standards for OSCC diagnosis, but they are time-consuming, invasive, and do not always enable the patient’s compliance, mainly in cases of follow-up with the need for more biopsies. The use of adjunctive noninvasive imaging techniques improves the diagnostic approach, making it faster and better accepted by patients. The present review aims to focus on the most consolidated diagnostic techniques, such as vital staining and tissue autofluorescence, and to report the potential role of some of the most promising innovative techniques, such as narrow-band imaging, high-frequency ultrasounds, optical coherence tomography, and in vivo confocal microscopy. According to their contribution to OSCC diagnosis, an ideal three-step diagnostic procedure is proposed, to make the diagnostic path faster, better, and more accurate.

show abstract

The use of intraoral ultrasound in the characterization of minor salivary gland malignancy: report of two cases

Cited by 9 publications

References 13 publications

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Adenoid Cystic Carcinoma of Salivary Glands: A Ten-Year Review and an Assessment of the Current Management, Surgery, Radiotherapy, and Chemotherapy

Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors

Noninvasive Imaging Methods to Improve the Diagnosis of Oral Carcinoma and Its Precursors: State of the Art and Proposal of a Three-Step Diagnostic Process

Contact Info

Product

Resources

About