The use of intravenous dramamine to shorten the time of labor and potentiate analgesia

Rotter, Carl W.; Whitaker, Jack L.; Yared, Joseph

doi:10.1016/0002-9378(58)90832-9

Cited by 7 publications

(3 citation statements)

References 3 publications

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“…Low doses produced sedation, reduced REM sleep, and reduced breathing activity; higher doses led to hypoxemia, acidemia, tachycardia, and transiently increased breathing activity. As seen in our patient, diphenhydramine and its chlorotheophylline salt, dimenhydrinate (Dramamine®) can exert oxytocic effects [11][12][13]. A study of dimenhydrinate in human labor (100 mg IV over 3.5 min) demonstrated increased amplitude and frequency of contractions.…”

Section: Discussionmentioning

confidence: 77%

The treatment of maternal and fetal anticholinergic toxicity with physostigmine

Stellpflug

Bangh²,

Cole

2018

Toxicology Communications

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A 20-year-old female at 36 weeks gestation ingested an unknown amount of diphenhydramine in a suicide attempt. She had a witnessed tonic-clonic seizure at home. Upon arrival to the emergency department, she was tachycardic with a pulse of 166, and confused. Fetal heart rate was 200-210 with poor variability. After being lavaged and given activated charcoal, the patient was given a small dose of intravenous physostigmine. Her pulse rapidly decreased from 134 to 121 beats/min and her mental status improved. The fetal pulse decreased from 192 to 182 b/m within 10 min. This case suggests that physostigmine can be used safely and effectively in pregnant women to treat signs and symptoms of severe anticholinergic poisoning in both the patient and fetus.

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Section: Discussionmentioning

confidence: 77%

The treatment of maternal and fetal anticholinergic toxicity with physostigmine

Stellpflug

Bangh²,

Cole

2018

Toxicology Communications

View full text Add to dashboard Cite

show abstract

“…The theory which has gained much popularity and received widespread support was put forward by Rotter et al in 1958. Varying amounts of cervical trauma occur as a consequence of all labours.…”

Section: Discussionmentioning

confidence: 99%

“…Centrally, the effects of dimenhydrinate resemble the antispasmodic actions of atropine. Its sedative effect, usually classified as a side effect in the ambulatory patient, has been noted to be a desirable quality in the parturient (Rotter et al, 1958). The undesirable side effects of dimenhydrinate include tinnitus, blurred vision, diplopia, insomnia, tremors, nausea, vomiting, hypotension and headache.…”

Section: Pharmacologymentioning

confidence: 97%