The use of ion-selective electrodes in the determination of drug substances

Electroanalytical determination of sildenafil in Viagra tablets using screen-printed and conventional carbon paste electrodes

“…On the other hand, application of potentiometric sensors in the field of pharmaceutical and biomedical analysis have been advocated [13]. The approach provides simple, fast, and selective technique for determination of various drugs [13][14][15][16][17][18]. However, as far as the available literature is concerned, very little is known about the use of this technique for Viagra quantification [19,20].…”

Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine

“…In recent decades potentiometric membrane ion-selective electrodes (ISEs) have been used in pharmaceutical and biological analyses [20-29] because these sensors offer the advantage of simple design and operation, low cost, fast response, low detection limit, adequate selectivity, good accuracy, wide concentration range, applicability to coloured and turbid solutions and possible interfacing with automated and computerized systems. However, a thorough literature survey has revealed no methods that use selective electrodes for the determination of sulpiride.…”

Flow‐Injection Analysis of Dopamine in Injections with a Periodate‐Selective Electrode

“…This system, a simple, inexpensive, and easily operated FIA manifold, combines the simplicity of an IO 4 − oxidation/reduction reaction with the selectivity, speed, low cost, and high reproducibility of potentiometric determinations in pharmaceutical preparations. 26 Moreover, the construction of a new IO 4 − -selective electrode with a less soluble ion exchanger led to an increase in the analytical working range. This feature allowed dopamine determinations with higher sensitivity than that of glycerol monitoring.…”