The use of "alternative grains," also known as ancient grains, climate-smart grains, nutrigrains, or traditional grains, like sorghum and millets in modern food products, is becoming common across the world. This is taking place in order to address several socioeconomic trends, especially changing lifestyles (e.g., urbanization, working mothers, and single-parent families) and also consumer nutrition, health, and ethical concerns about obesity and type 2 diabetes, allergies, and environmental sustainability (Taylor and Awika, 2017). For example, sorghum and millets are increasingly being explored in gluten-free applications targeting consumers who suffer from celiac disease and intolerances to wheat and related cereals. Another perceived advantage of sorghum and millets is their completely genetically modified organism (GMO)-free nature that can allow them to be used in specialty products such as organic foods and humanitarian aid for countries with GMO restrictions. This chapter is structured with the purpose of providing innovative ideas to enable mainstreaming of sorghum and millets in modern foods, against this background of prevailing socioeconomic trends, all of which provide opportunities for creating a sustained "demand pull" for these crops. Opportunities for creation of sustainable business enterprises to address the consumer demand for nutritious value-added products from these climate-smart, hardy crops (see Chapter 1) are discussed, with a focus on technology as well as the "ecosystem" required to nurture and sustain these business enterprises. The chapter specifically focuses on applications of sorghum and millets in readyto-eat (RTE) foods and other modern convenience-type foods and beverages, plus some feed products and the various technologies used for their manufacture, for example, extrusion cooking. To highlight the global nature of sorghum and millet food, beverage, and feed product development, the chapter brings perspectives and provides product examples from the United States, India, and Africa. Products covered include breakfast cereals and snacks, precooked pasta, unleavened flatbreads, health-promoting products, fortified blended foods (FBFs) used in government-sponsored aid programs, beers and nonalcoholic malt drinks, other nonalcoholic fermented or powder-based beverages, plus pet food and aquatic feed. These innovative applications point toward a gradual mainstreaming of sorghum and millets against the background of increasing demand for alternative grains as discussed previously.