The Use of Long-Acting Contraceptives in Adolescents

Approach to the Adolescent Girl as She Transits from Irregular to Regular Menstrual Cycles

“…16 A short course of conjugated estrogen (Premarină) 1.25 mg/d or estradiol (Estraceă) 2 mg/d for 7-21 days is the preferred treatment for persistent bleeding in adolescents who use a long-term, progestin-only contraceptive such as Depo-Proveraă. 17 Non-steroidal anti-inflammatory drugs (NSAID) have also been shown to diminish bleeding during a regular menstrual period as well as reduce bleeding associated with the use of a long-term progestin-only contraceptive. 18 Because the local fibrinolytic activity in the uterus is increased in patients with abnormal uterine bleeding, antifibrinolytic therapy can also be considered in the management of adolescents with severe abnormal bleeding.…”

Permeation measurement of gestodene for some biodegradable materials using Franz diffusion cells

“…During the past decades, women had been looking forward to alternatives to the short-acting contraceptives and there were many studies with focus on long-acting contraceptives (Baldwin and Edelman, 2013, Neukom et al, 2011, Ferreira et al, 2014, Chen and Chen, 2007). Consistent use of short-acting methods such as injectables and pills is under constant threat from difficulty of the ‘surprise’ in case of a forgotten pill, inconvenience of daily intake, onset of side effects and other factors (Harel and Cromer, 1999, Lara-Torre and Schroeder, 2002, Likis, 2002, Brache and Faundes, 2010). Long-acting contraceptive methods such as intrauterine contraceptive device (Thonneau and Almont, 2008, Jacques et al, 1986), implants (Bhatia et al, 2011) and injections (Thurman et al, 2013, Rahimy et al, 1999) which could offer a long-period effect with good compliance (Urdl et al, 2005) and tolerance are more popular (Archer et al, 2004).…”