The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide

Abstract

Graphical abstract

Impact of oxygen supply on surfactin biosynthesis using brewery waste as substrate

“…Organic Carbon was analyzed by Total Organic Carbon Analyser (TOC -SHIMADZU) and Total Nitrogen by enzymatic-colorimetric method (Kit Gold Analisa Diagnostics). The results were reported in [29].…”

A critical review on the biotechnological potential of Brewers’ waste: Challenges and future alternatives

“…The hot trub has been applied as a carbon source for the production of Surfactin ( Nazareth et al, 2020 ). Surfactin is a natural microbiocide competently applied to diminish the surface tension of liquid phases associated with gas, or interfacial tension among immiscible fluids.…”

“…They may also alter the surface qualities that influence the adhesion of the microbes, disrupt membranes, trigger cell lysis, and interfere with the development of biofilms and quorum sensing. Surfactin produced from brewery trub has been shown to exhibit antibacterial effects against the pathogens Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus , and Staphylococcus epidermidis ( Nazareth et al, 2020 ). Hence, the waste trub can be applied in the pharmaceutical industries for cheap and easy production of Surfactin.…”

Chemical structure, properties and potential applications of surfactin, as well as advanced strategies for improving its microbial production

“…Cheap waste biomass is now being used as a substitute for refined carbon and nitrogen sources in order to reduce costs. For example, in a study of surfactin production using low-cost beer waste as a carbon source, B. subtilis produced surfactin at an amount of 210.11 mg/L for 28 hours, with inhibition activity against all tested bacteria, and complete inhibition was achieved against Pseudomonas aeruginosa , indicating that surfactin produced from low-cost substrates has the potential to be a promising bactericide [75] . In addition, a number of studies have been conducted on the production of surfactin from hydrolysate, glutamate, wine lees and other wastes with the aim of reducing its production cost by using cheap carbon sources, and the final yield of surfactin was around 500 mg/L [76] , [77] .…”