The use of low dose octreotide prophylaxis in pancreatic transplants with enteric drainage. Results of a prospective randomized single center trial

Hesse, Uwe; Meester, D.; Troisi, Roberto; Cathenis, Koen; Lameire, Norbert; Hemptinne, Bernard de

doi:10.1111/j.1399-0012.2005.00208.x

Cited by 17 publications

(11 citation statements)

References 15 publications

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“…The 63 included articles comprised of 2 meta-analyses, 47 39 cohort studies, 3,6,8,[12][13][14][15][16][17][18][19][20][23][24][25][26][27][28]30,[32][33][34][35][36][37]39,[41][42][43]45,46,48 and 22 conference abstracts. 4,7,[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] All studies reported thrombosis in pancreas allograft transplantation.…”

Section: Study Characteristicsmentioning

confidence: 99%

Risk Factors for Early Pancreatic Allograft Thrombosis Following Simultaneous Pancreas-Kidney Transplantation: A Systematic Review

Blundell

Shahrestani

Lendzion

et al. 2020

Clin Appl Thromb Hemost

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Simultaneous pancreas-kidney (SPK) transplantation remains the most effective treatment for providing consistent and long-term euglycemia in patients having type 1 diabetes with renal failure. Thrombosis of the pancreatic vasculature continues to contribute significantly to early graft failure and loss. We compared the rate of thrombosis to graft loss and systematically reviewed risk factors impacting early thrombosis of the pancreas allograft following SPK transplantation. We searched the MEDLINE, EMBASE, The Cochrane Library, and PREMEDLINE databases for studies reporting thrombosis following pancreas transplantation. Identified publications were screened for inclusion and synthesized into a data extraction sheet. Sixty-three studies satisfied eligibility criteria: 39 cohort studies, 22 conference abstracts, and 2 meta-analyses. Newcastle-Ottawa Scale appraisal of included studies demonstrated cohort studies of low bias risk; 1127 thrombi were identified in 15 936 deceased donor, whole pancreas transplants, conferring a 7.07% overall thrombosis rate. Thrombosis resulted in pancreatic allograft loss in 83.3% of reported cases. This review has established significant associations between donor and recipient characteristics, procurement and preservation methodology, transplantation technique, postoperative management, and increased risk of early thrombosis in the pancreas allograft. Further studies examining the type of organ preservation fluid, prophylactic heparin protocol, and exocrine drainage method and early thrombosis should also be performed.

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Section: Study Characteristicsmentioning

confidence: 99%

Risk Factors for Early Pancreatic Allograft Thrombosis Following Simultaneous Pancreas-Kidney Transplantation: A Systematic Review

Blundell

Shahrestani

Lendzion

et al. 2020

Clin Appl Thromb Hemost

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“…Pancreatitis was seen in one patient in the octreotide group and no patients in the no octreotide group. This difference was not statistically significant (p = 0.46) [25].…”

Section: Pancreas Transplantationmentioning

confidence: 67%

“…Interestingly however, alcohol and cholelithiasis have not been shown to be associated with acute pancreatitis in this patient population [40,41]. Further, low-dose octreotide showed no association with acute pancreatitis [25].…”

Section: Kidney Transplantationmentioning

confidence: 82%

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Pancreatitis in Solid Organ Transplant Patients: A Review of the Literature

Graham¹,

Itô²,

Busuttil³

et al. 2019

obm hg

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Acute pancreatitis is a highly morbid condition, which is widely recognized and well-defined in the general population. In this article, we summarized the current literature on acute pancreatitis in the setting of solid organ transplant, including patients who are listed for or have undergone transplantation. The incidence of acute pancreatitis in the solid organ transplant patient population ranges from 1-35%. Rates are lowest in cardiac and liver transplant patient populations and highest in the kidney and pediatric intestine transplant populations. The literature is summarized by organ transplant type, including cardiac, lung, pancreas, kidney, intestine, and liver. Our review suggests that providers should have a high index of suspicion for acute pancreatitis in the solid organ transplant population in order to mitigate the morbidity associated with this disease in a highly vulnerable patient population.

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“…Considering drain placement and management after pancreatic resection, controversies have recently emerged from both randomized and nonrandomized clinical studies investigating the role of ID in increasing POPF and postoperative morbidity as well as prolonged hospital stay. Although some authors advocate early ID removal to prevent intra-abdominal infection, in clinical practice, surgically placed drains are usually removed at surgeon discretion once occurrence of POPF or other abdominal complications has been excluded [2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Drain management after pancreatic resection: state of the art

Giovinazzo

Butturini

Salvia

et al. 2011

J Hepato Biliary Pancreat

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Background Placement of intraperitoneal drain (ID) after abdominal surgery is a common practice. Postoperative pancreatic fistula (POPF), incidence of which ranges from 2% to more than 30%, represents the most common major complication after pancreatic resection. The goal of this paper is to review the state of the art in ID management after pancreatic resection. Methods Data from randomized controlled trials (RCT) are reported together with data from our institution in the period before and after the start of the two reported RCTs. Results One thousand five hundred eighty patients underwent surgical resection for pancreatic lesions at our institution from 1990 to 2010. The overall rate of POPF was 23% before and 19.5% after (P = 0.24) the performance of the RCTs. Both postoperative morbidity and average in-hospital stay were higher in the period before the RCTs (13.6 ± 11.4 versus 13.4 ± 10.3 days, respectively). Conclusions POPF is a complex and multifactorial complication after pancreatic surgery. On the basis of the present results and review of the RCTs, the value of ID and its management after pancreatic surgery remain unclear.

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The use of low dose octreotide prophylaxis in pancreatic transplants with enteric drainage. Results of a prospective randomized single center trial

Cited by 17 publications

References 15 publications

Risk Factors for Early Pancreatic Allograft Thrombosis Following Simultaneous Pancreas-Kidney Transplantation: A Systematic Review

Risk Factors for Early Pancreatic Allograft Thrombosis Following Simultaneous Pancreas-Kidney Transplantation: A Systematic Review

Pancreatitis in Solid Organ Transplant Patients: A Review of the Literature

Drain management after pancreatic resection: state of the art

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