The use of low intensity pulsed ultrasound in the foot and ankle

Rashid, Mustafa S.; Tourné, Y.; Teoh, Kar Hao

doi:10.1302/2058-5241.6.200045

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…Many studies have proven that LIPUS therapy is an excellent conservative therapeutic approach for bone and cartilage tissues. 6 , 11 , 12 Among the non-surgical therapy alternatives for tendon injuries, the use of LIPUS is one of the most explored. However, no research demonstrating the efficacy of the treatment supported by in vivo investigations exists.…”

Section: Discussionmentioning

confidence: 99%

Effect of the low-intensity pulsed ultrasound therapy on healing of Achilles tendinopathy in a rat model

Kurtulmuş,

Çelebi,

Bektaş

et al. 2024

Acta Orthopaedica et Traumatologica Turcica

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Objective: This study aimed to investigate the effect of the low-intensity pulsed ultrasound (LIPUS) on the healing of Achilles tendinopathy in a rat model induced by type 1 collagenase. Methods: The study was conducted on 144 Achilles tendons of 72 Wistar albino female rats with typical activity and weighing 300-350 g. The model of Achilles tendinopathy was created by injecting type 1 collagenase. According to the sampling time, 4 groups served as the control group, while 8 groups received treatment at varying periods. Low-intensity pulsed ultrasound therapy was initiated in 8 groups at 1, 7, and 15 days. Treatment was extended for 1 and 2 weeks. Achilles tendons were removed from the treatment and control groups on the 15th, 21st, 30th, and 45th days for biomechanical and pathologic examination. Results: Compared to the control groups, LIPUS treatment administered in the first days of the proliferation phase increased tensile strength by approximately 30%, modulus of elasticity by approximately 53%, fibrillar appearance by 53%, and inflammation by 53%-33% in a shorter time. It was also demonstrated that starting treatment in the first days of the proliferation phase resulted in comparable success even with 1-week treatment compared to 2-week treatment. Conclusion: Low-intensity pulsed ultrasound therapy can provide positive results in managing Achilles tendinopathy in the rat model. Its capacity to shorten recuperation time has piqued the interest of conservative treatment approaches. As a result, more clinical research is required.

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Section: Discussionmentioning

confidence: 99%

Effect of the low-intensity pulsed ultrasound therapy on healing of Achilles tendinopathy in a rat model

Kurtulmuş,

Çelebi,

Bektaş

et al. 2024

Acta Orthopaedica et Traumatologica Turcica

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“…A case report showed that a patient with a Jones fracture was treated with continuous cryotherapy and proprioceptive training, and the patient was able to walk normally with full weight bearing after 12 days of treatment [ 17 ]. Low-intensity pulsed ultrasound has been found to be effective in enhancing the healing rate of scars, including those in the foot and ankle [ 18 ]. Muscle strengthening exercises are crucial in rehab regimens, enhancing flexibility, stability, and confidence while also preventing falls and restoring mobility, thereby improving patients' quality of life and reducing discomfort [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Effective Rehabilitation of a Lisfranc Fracture in a 25-Year-Old Male Patient: A Case Report

Chitlange,

Ramteke

2024

Cureus

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A dislocation or break of the tarsometatarsal joint in the foot is referred to as a Lisfranc fracture, sometimes called a Lisfranc injury. It can be caused by less stressful mechanisms like a twisting fall as well as high-energy events like car crashes or falls from heights. Swelling, bruises, and midfoot pain that gets worse when standing or walking are some of the symptoms. The damage may only affect the ligaments or the foot's bony structures. Nonoperative or surgical treatment may be part of the management, depending on how severe the injury is. In order to realign and stabilize the bones, open reduction internal fixation with Kirschner wires (K-wires) is a common surgical procedure. In this case, a 25-year-old male patient complained of left foot pain and wound. He gave a history of a left leg stuck in the harvester. Immediately, he was taken to a local hospital, where a dressing of his left foot was done. He was referred to a super specialty hospital where an investigation, like an X-ray, was done, which revealed a Lisfranc fracture. K-wire was applied to fix the Lisfranc fracture. Further on, rehabilitation was started to restore mobility, regain full range of motion, and develop muscle strength. American Orthopedic Foot and Ankle Score (AOFAS) and Lower Extremity Functional Scale (LEFS) were used as outcome measures.

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“…As a safe and non-invasive approach, LIPUS has shown great potential in tissue repair and resolution of inflammation in various diseases. [32][33][34][35] Of note, the therapeutic effects of LIPUS on cardiovascular diseases have been reported in recent years. [10][11][12][13][14] In our present study, we showed that LIPUS therapy provided a great benefit in both acute and chronic DOX injury models, including the improvement of cardiac contractile function, the attenuation of myocardial injury and cellular apoptosis, as well as the alleviation of oxidative stress and cardiac fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, effective and safe strategies remain limited. As a safe and non‐invasive approach, LIPUS has shown great potential in tissue repair and resolution of inflammation in various diseases 32–35 . Of note, the therapeutic effects of LIPUS on cardiovascular diseases have been reported in recent years 10–14 .…”

Section: Discussionmentioning

confidence: 99%

Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils

Zhu

Wang

et al. 2023

Bioengineering & Transla Med

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Doxorubicin (DOX)‐induced cardiotoxicity limits its broad use as a chemotherapy agent. The development of effective and non‐invasive strategies to prevent DOX‐associated adverse cardiac events is urgently needed. We aimed to examine whether and how low‐intensity pulsed ultrasound (LIPUS) plays a protective role in DOX‐induced cardiotoxicity. Male C57BL/6J mice were used to establish models of both acute and chronic DOX‐induced cardiomyopathy. Non‐invasive LIPUS therapy was conducted for four consecutive days after DOX administration. Cardiac contractile function was evaluated by echocardiography. Myocardial apoptosis, oxidative stress, and fibrosis were analyzed using terminal deoxynucleotidyl transferase‐mediated dUTP nick end labelling (TUNEL) staining, dihydroethidium (DHE) staining, and picrosirius red staining assays. RNA‐seq analysis was performed to unbiasedly explore the possible downstream regulatory mechanisms. Neutrophil recruitment and infiltration in the heart were analyzed by flow cytometry. The S100a8/a9 inhibitor ABR‐238901 was utilized to identify the effect of S100a8/a9 signaling. We found that LIPUS therapy elicited a great benefit on DOX‐induced heart contractile dysfunction in both acute and chronic DOX models. Chronic DOX administration increased serum creatine kinase and lactate dehydrogenase levels, as well as myocardial apoptosis, all of which were significantly mitigated by LIPUS. In addition, LIPUS treatment prevented chronic DOX‐induced cardiac oxidative stress and fibrosis. RNA‐seq analysis revealed that LIPUS treatment partially reversed alterations of gene expression induced by DOX. Gene ontology (GO) analysis of the downregulated genes between DOX‐LIPUS and DOX‐Sham groups indicated that inhibition of neutrophil chemotaxis might be involved in the protective effects of LIPUS therapy. Flow cytometry analysis illustrated the inhibitory effects of LIPUS on DOX‐induced neutrophil recruitment and infiltration in the heart. Moreover, S100 calcium binding protein A8/A9 (S100a8/a9) was identified as a potential key target of LIPUS therapy. S100a8/a9 inhibition by ABR‐238901 showed a similar heart protective effect against DOX‐induced cardiomyopathy to LIPUS treatment. LIPUS therapy prevents DOX‐induced cardiotoxicity through inhibition of S100a8/a9‐mediated neutrophil recruitment to the heart, suggesting its potential application in cancer patients undergoing chemotherapy with DOX.

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The use of low intensity pulsed ultrasound in the foot and ankle

Cited by 6 publications

References 18 publications

Effect of the low-intensity pulsed ultrasound therapy on healing of Achilles tendinopathy in a rat model

Effect of the low-intensity pulsed ultrasound therapy on healing of Achilles tendinopathy in a rat model

Effective Rehabilitation of a Lisfranc Fracture in a 25-Year-Old Male Patient: A Case Report

Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils

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