The use of magnesium sulfate in the measurement of circulation time

Bernstein, Mitchell; Simkins, Samuel

doi:10.1016/s0002-8703(39)90492-8

Cited by 22 publications

(1 citation statement)

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“…In human subjects. Bernstein and Simkins (1939) used magnesium sulphate to measure the circulation time, and noted that, after receiving an intravenous injection of tbe drug, their subjects all experienced a transient sensation of heat, first in the phar\nx, then progressively in the face, one or both hands, the perineum and, finally, in the feet. Haury (1939) gave intravenous injections of magnesium sulphate and observed an increase in the volume of the foot which ho attributed to vasodilatation.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Magnesium Sulphate on the Blood Vessels of the Upper Limb in Man

Frewin

Whelan

1971

Aust J Exp Biol Med

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Summary. Magnesium sulphate, given into the brachial artery, has been shown to have a dilator action on the blood vessels of the human forearm.The dilatation affects the vessels of both skin and muscle and is not due to stimulation of the ^-receptors to a cholinergic mechanism or to the release of histamine.The vasodilator action of magnesium sulphate on the forearm does not jippear to be influenced by the s>nipathetic ner^'es, but is abolislied by the simultaneous infusion of calcium f^luconate into the bracliial artery. INTRODUCTION.Magnesium sulphate has been used intravenously in the treatment of eclampsia in pregnancy to reduce blood pressure, but its method of action is not clear. Meltzer and .Auer (1906) reported a fall in blood pres.surc with intravenous administration of magnesium salt in rabbits and attributed the response to a depressant action of this substance on the vasomotor centre. Smith, Winkler and HofF (1939) showed that the continuous intravenous administration of magnesium sulpbate at low doses in the anaesthetised dog and cat produced an increase in heart rate which gave way to a bradycardia as the serum concentration of the magnesium ion increased. Tbey noted a depression of intracardiac conduction. In a subsequent paper, Winkler, Ho0 and Smith (1940) reported that injections of magnesium salt in the dog produced a fall in blood pressure associated with cutaneous vasodilatation w^hen the serum concentration of the ion reached 3-4 mg.%, and cardiac block and arrest when the concentration of magnesium was above 20 mg.%.In human subjects. Bernstein and Simkins (1939) used magnesium sulphate to measure the circulation time, and noted that, after receiving an intravenous injection of tbe drug, their subjects all experienced a transient sensation of heat, first in the phar\nx, then progressively in the face, one or both hands, the perineum and, finally, in the feet. Haury (1939) gave intravenous injections of magnesium sulphate and observed an increase in the volume of the foot which ho attributed to vasodilatation. Browne (1964) has used intramuscular or intravenous magnesium sulphate in the treatment of peripheral arterial disease, and suggests that the beneficial results appear to be due mainly to a prolonged

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Section: Introductionmentioning

confidence: 99%