2017
DOI: 10.1007/s00253-017-8707-5
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The use of marine-derived fungi for preparation of enantiomerically pure alcohols

Abstract: A highly enantioselective and minimally polluting approach to optically pure chiral alcohols is developed using cheap, readily available and sustainable marine-derived fungi as catalysts. An evaluation of the synthetic potential of 13 Chinese marine fungi was performed to screen for enantioselective reduction of 13 aromatic ketones from different compound classes as substrates. Good yields and excellent enantioselectivities were achieved with this method. In details, first the effects of several crucial variab… Show more

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Cited by 17 publications
(18 citation statements)
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“…To compare the biocatalytic activity of free and immobilized G. candidum AS 2.361 cells for the asymmetric reduction of ketones, both free cells and immobilized cells (on agar and calcium alginate) were used as catalysts for the reactions. Free cells were obtained as described previously [ 19 ]. Immobilized cells were obtained according to the protocols described in the Experimental Section 3.2 .…”
Section: Resultsmentioning
confidence: 99%
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“…To compare the biocatalytic activity of free and immobilized G. candidum AS 2.361 cells for the asymmetric reduction of ketones, both free cells and immobilized cells (on agar and calcium alginate) were used as catalysts for the reactions. Free cells were obtained as described previously [ 19 ]. Immobilized cells were obtained according to the protocols described in the Experimental Section 3.2 .…”
Section: Resultsmentioning
confidence: 99%
“…Organic solvents were removed using a rotary evaporator. Free cells of G. candidum AS 2.361 were obtained as described in a previous report by our group [ 19 ]. Geotrichum candidum AS 2.361 used in this study was deposited and commercially available in Guangdong Culture Collection Center ( ), which belongs to the World Federation for Culture Collections (Budapest Notification no.…”
Section: Methodsmentioning
confidence: 99%
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“…Indeed, fungi host novel enzymes showing optimal activities at extreme values of salt concentrations, pH and temperature, compared to enzymes isolated from terrestrial origins [ 51 , 52 , 53 ]. These advantages, in addition to their chemical and stereochemical properties and readily available sources (e.g., sea sources of enzymes represented by microorganisms or fungi, plants or animals; ease of growth), make marine enzymes ideal biocatalysts for fine chemistry and pharmaceutical sectors; these enzymes should be broadly explored [ 28 , 29 , 30 , 48 , 54 , 55 , 56 ].…”
Section: Discussionmentioning
confidence: 99%