The use of maropitant to prevent vomiting induced by epidural administration of preservative free morphine through an epidural catheter in a dog

Mathis, Alessandra; Lee, Karla; Alibhai, Hatim

doi:10.1111/j.1467-2995.2011.00645.x

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…The NK 1 receptor antagonist aprepitant is successfully used for preventing acute and delayed CINV . The NK 1 receptor antagonists are also effective against MS‐induced emesis in animals but not in humans . Recent findings have demonstrated that MS is associated with impaired endocannabinoid activity .…”

Section: Motion Sickness Medicationsmentioning

confidence: 99%

Motion Sickness: Current Knowledge and Recent Advance

et al. 2015

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Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS-related neuroendocrine. Single-nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual-vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms.

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Section: Motion Sickness Medicationsmentioning

confidence: 99%

Motion Sickness: Current Knowledge and Recent Advance

et al. 2015

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“…Maropitant provides antimemetic effects by preventing the substance P from binding with the NK 1 receptors located in the vomiting center and the chemo-trigger zone [5, 23]. On the other hand, the substance P binds to the NK 1 receptors located in the dorsal horn of spinal cord with high affinity and produces increases in pain signal in cats [11].…”

mentioning

confidence: 99%

Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

Fukui

Ooyama

Tamura

et al. 2017

The Journal of Veterinary Medical Science

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Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period. On each occasion, maropitant (1 mg/kg) alone, carprofen (4 mg/kg) alone, a combination of maropitant (1 mg/kg) and carprofen (4 mg/kg), or saline (0.1 ml/kg) was subcutaneously administered at 1 hr prior to the first electrical stimulation for the sevoflurane MAC-BAR determination. The sevoflurane MAC-BAR was significantly reduced by maropitant alone (2.88 ± 0.73%, P=0.010), carprofen alone (2.96 ± 0.38%, P=0.016) and the combination (2.81 ± 0.51%, P=0.0003), compared with saline (3.37 ± 0.56%). There was no significant difference in the percentage of MAC-BAR reductions between maropitant alone, carprofen alone and the combination. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction. Anesthetic premedication with a combination of maropitant and carprofen may not provide any further sparing effect on anesthetic requirement in dogs.

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“…Em um estudo que comparou a associação da acepromazina com a morfina para o controle do vômito, foi obtida significativa redução, quando comparada ao uso de morfina isoladamente (KOH et al, 2014). No presente estudo, não foi possível verificar tal efeito antiemético da acepromazina, já que ambos os fármacos foram administrados juntos e o período de latência da morfina é menor que o da acepromazina (MATHIS et al, 2011). Para melhor aproveitar o efeito antiemético da acepromazina, talvez a aplicação com 15 a 20 minutos de antecedência da administração da morfina, possa diminuir ou excluir a ocorrência de vômito, o que é pouco aplicável na rotina.…”

Section: Resultsunclassified

Influência Da Acepromazina Sobre Os Parâmetros Cardiovasculares, Respiratórios, Hematológicos E Urinários Em Cães Submetidos À Orquiectomia

Boanova¹,

Macarini²,

Andrades³

et al. 2022

SAH

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A acepromazina é amplamente utilizada como medicação pré-anestésica em pequenos animais, especialmente em cães. Este estudo teve o objetivo de avaliar o uso da acepromazina em cães submetidos à orquiectomia eletiva, quanto aos efeitos na anestesia, nos sinais vitais, hematológicos e urinários. Foram avaliados 12 cães machos, com idade entre um e cinco anos, peso médio de 17 ± 5 kg. Os animais foram alocados aleatoriamente em dois grupos: o grupo AM recebeu acepromazina 0,05 mg/kg associada à morfina 0,5 mg/kg e o grupo M recebeu apenas morfina 0,5 mg/kg, ambos por via intramuscular, como medicação pré-anestésica. Ambos os grupos receberam indução anestésica com propofol, manutenção com isoflurano e bloqueio testicular com lidocaína. Além dos parâmetros transoperatórios, antes e depois da cirurgia, foram coletados urina e sangue para realização da análise urinária e hemograma. O grupo AM apresentou menor dose de propofol, valores de pressão arterial, frequência cardíaca, respiratória e temperatura. No hemograma, os pacientes do grupo AM tiveram diminuição do hematócrito, proteína plasmática, leucócitos totais no final do procedimento, sem alterações significativas na urinálise. Concluí-se que a acepromazina embora reduza a necessidade de propofol para indução anestésica, também reduz os valores de pressão arterial, temperatura, frequência cardiaca, respiratória, células sanguíneas e proteínas totais.

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The use of maropitant to prevent vomiting induced by epidural administration of preservative free morphine through an epidural catheter in a dog

Cited by 11 publications

References 6 publications

Motion Sickness: Current Knowledge and Recent Advance

Motion Sickness: Current Knowledge and Recent Advance

Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs

Influência Da Acepromazina Sobre Os Parâmetros Cardiovasculares, Respiratórios, Hematológicos E Urinários Em Cães Submetidos À Orquiectomia

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