The use of marrow-derived stem cells to accelerate healing in chronic wounds

Abstract

Adult bone marrow-derived stem cells may aid the healing of chronic lower extremity wounds by transplanting a population of progenitor cells locally into the wound. We present results from three cases in which bone marrow aspirate containing marrow-derived cells was applied/injected locally into complex lower extremity chronic wounds of differing aetiologies. Our case series suggest that bone marrow aspirate, applied topically and injected into the wound periphery, may be a useful and potentially safe adjunct to wound simplification and ultimate closure.

Bone Marrow Mesenchymal Cells: How Do They Contribute to Tissue Repair and Are They Really Stem Cells?

“…In patients who received a sex-mismatched bone marrow transplantation, some hepatocytes were shown to originate from the donor (Thomas 2000). In addition to these cases, MSCs are reported to repair the heart (myocardial infarction), neural tissue (stroke and spinal cord injury), airway (tracheal obstruction), skin (dermal ulcer), skeletal muscle (muscle degeneration), and intestine (ischemic intestinal diseases) (Adas et al 2011;Chopp et al 2000;Ferrari et al 1998;Grove et al 2011;Li et al 2000;Rogers et al 2008;Schachinger et al 2009). Thus, MSC transplantation has already been applied in the treatment of many kinds of intractable diseases.…”

“…MSCs are also applicable for the repair of skeletal muscle degeneration (de la Garza-Rodea et al 2011;Ferrari et al 1998), ischemic colonic anastomoses (Adas et al 2011), chronic severe wounds such as skin ulcers (Rogers et al 2008), and airway (trachea) obstruction (Grove et al 2011). Apart from these hopeful results using MSCs in clinical applications, a question still remains to be answered.…”

Recent Innovation in Pretreatment for Skin Grafts Using Regenerative Medicine in the East

“…These authors reported that bone marrow-derived cultured mesenchymal stem cells accelerated the healing of cutaneous wounds (Falanga et al, 2007). A similar clinical approach has been performed by Rogers et al (2008) and reported that topical application and injection into the wound periphery of bone marrow can be a useful and a potentially safe adjunct to wound simplification and ultimate closure (Rogers et al, 2008). It was reported that locally applied mononuclear bone marrow cells restored angiogenesis and promoted wound healing of an ulcer of the lower leg in a type 2 diabetic patient (Humpert et al, 2005).…”

Stem Cell and Stem Cell-Derived Molecular Therapies to Enhance Dermal Wound Healing

“…The main populations are hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), and EPCs. Bone marrow aspirate continues to be investigated as a potential wound healing therapy [ 64 ] and recently a small, randomized clinical study demonstrated that a single local application of bone marrow-derived cells increased the healing rate, although this effect did not persist [ 65 ]. However, investigation into exogenous stem cell therapies for chronic wounds has focused predominantly on the use of isolated MSCs.…”