The paper presents the results of tests of tribological wear of two Co-Cr-Mo alloys (Wironit LA) andCo-Cr-Mo-W (Colado CC) used to make skeletal prostheses, combined works, implants and metalframeworks for ceramics. The test samples were centrifugally cast using the lost wax method and subjected tohardness measurements, microscopic observations, and a quantitative description of the microstructure. SEMexaminations and EDS analysis of micro-areas on dendritic arms and interdendritic areas were performedtogether. The abrasive wear resistance tests with the use of a T-05 tester in the friction system roller-blockwere conducted in a dry sliding contact under the conditions of a metal-metal contact with the load of 100 Nand for two friction paths, 500 and 1000 m.