The use of metronidazole gel to control the smell of malodorous lesions

Newman, Vicky A.; Allwood, M. C.; Oakes, RA

doi:10.1177/026921638900300412

Cited by 34 publications

(12 citation statements)

References 5 publications

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“…The subjects of this study were patients with a fungating tumor and malodor from infection, and other types of malodorous fungating tumors were not evaluated. In Japan, most studies have investigated the effects of topical MTZ on malodorous fungating tumors of breast cancer patients [ 5 , 8 , 13 – 29 ], but few investigated the efficacy and safety of topical MTZ on malodorous fungating wounds that are unrelated to breast cancer [ 30 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013)

Watanabe

Shimo

Tsugawa

et al. 2015

Support Care Cancer

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PurposeMalignant fungating tumors are neoplastic tumors associated with skin ulcers, which are susceptible to microbial colonization. Bacterial infection and proliferation may lead to malodor causing distress to patients. Metronidazole—an effective agent against anaerobes—may contribute to deodorization and improvement in quality of life (QOL). This study investigated the efficacy and safety of topical metronidazole 0.75 % gel for alleviation of malodor in anaerobically infected fungating neoplastic tumors.MethodsThis was a multicenter, open-label, non-controlled, phase III study including subjects aged 20 years or older with cutaneous fungating tumors releasing malodor (minimum score of 2 (mildly offensive smell) on a scale from 0 (no smell) to 4 (extremely offensive smell) based on investigator’s assessment). Subjects applied metronidazole 0.75 % gel once or twice daily at the investigator’s discretion for 14 days. Success was defined as an odor score of 0 or 1 at day 14, as assessed by the investigator. Patient satisfaction was assessed using a satisfaction questionnaire. Adverse events (AEs) that occurred after application of metronidazole 0.75 % gel were also reported.ResultsA total of 21 subjects at a median age of 65.0 years were enrolled. The success rate of deodorization at day 14 was 95.2 % (20/21 subjects). The patient satisfaction assessment showed that 71.4 % (15/21) of subjects were markedly or moderately improved. The treatment was well tolerated with only two AE cases of skin neoplasm bleeding (one mild and one moderate).ConclusionsMetronidazole 0.75 % gel is an effective and safe treatment for deodorization of malodorous fungating tumors.

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Section: Discussionmentioning

confidence: 99%

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013)

Watanabe

Shimo

Tsugawa

et al. 2015

Support Care Cancer

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“…Topical preparations such as metronidazole, clindamycin, honey, and sugar have been shown to be promising in this regard in various studies to date. [96][97][98] Despite widespread use of activated charcoal dressings in malodorous wounds, many publications to date tend to focus on wound healing rather than odor control. [99][100][101] The ability of these dressings to decrease wound odor is undeniable in respect to clinical experiences to date, but objective data of strictly charcoal compounds are lacking.…”

Section: Dressing Descriptionsmentioning

confidence: 99%

Wound Dressings and Comparative Effectiveness Data

Sood¹,

Granick²,

Tomaselli³

2014

Advances in Wound Care

609

288

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Injury to the skin provides a unique challenge, as wound healing is a complex and intricate process. Acute wounds have the potential to move from the acute wound to chronic wounds, requiring the physician to have a thorough understanding of outside interventions to bring these wounds back into the healing cascade. The development of new and effective interventions in wound care remains an area of intense research. Negative pressure wound therapy has undoubtedly changed wound care from this point forward and has proven beneficial for a variety of wounds. Hydroconductive dressings are another category that is emerging with studies underway. Other modalities such as hyperbaric oxygen, growth factors, biologic dressings, skin substitutes, and regenerative materials have also proven efficacious in advancing the wound-healing process through a variety of mechanisms. There is an overwhelming amount of wound dressings available in the market. This implies the lack of full understanding of wound care and management. The point of using advanced dressings is to improve upon specific wound characteristics to bring it as close to "ideal" as possible. It is only after properly assessing the wound characteristics and obtaining knowledge about available products that the "ideal" dressing may be chosen. The future of wound healing at this point remains unknown. Few high-quality, randomized controlled trials evaluating wound dressings exist and do not clearly demonstrate superiority of many materials or categories. Comparative effectiveness research can be used as a tool to evaluate topical therapy for wound care moving into the future. Until further data emerge, education on the available products and logical clinical thought must prevail.

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“…Anaerobes produce foul-smelling fatty acids as metabolic end products, and anaerobe elimination correlates with odor improvement 4 . Although oral metronidazole has been used to combat anaerobe infection, 5 many cases resulted in incomplete odor eradication and immediate recurrence upon therapy cessation 6 . Furthermore, long-term oral therapy may not be feasible because of the risk of developing antimicrobial resistance and adverse effects such as nausea, neuropathy, and a disulfiram-like reaction with alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

The use of metronidazole gel to control the smell of malodorous lesions

Cited by 34 publications

References 5 publications

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013)

Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013)

Wound Dressings and Comparative Effectiveness Data

Successful management of malodor from fungating tumors using crushed metronidazole tablets

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