“…The electronic database search identified a total of 4449 studies, out of which 18 studies involving 5821 patients were included in the final qualitative synthesis ( Figure 1 ). Of the included studies, 9 (50%) were randomized trials [ 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ] and 9 (50%) were non-randomized interventional/observational studies [ 11 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ] ( Table 1 , Table S3 ). Sixteen of 18 studies (89%) were conducted in high-income countries (HICs) [ 11 , 26 , 27 , 28 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 41 , 42 ], the majority ( n = 11) in the United States [ 11 , 26 , 28 , 29 , 33 , 34 , 35 , 36 , 38 , 40 , 41 ].…”