The use of nanocluster polyoxometalates in the bioactive substance delivery systems

Остроушко, А. А.; Gagarin, I.D.; Данилова, И. Г.; Гетте, И. Ф.

doi:10.17586/2220-8054-2019-10-3-318-349

Cited by 9 publications

(6 citation statements)

References 276 publications

(345 reference statements)

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“…An important aspect of the possible use of POM in the field of biomedicine is the possibility of iontophoretic, including percutaneous, transport of Keplerates and their conjugates into the body. These processes were considered in our previous work [179]. As is noted above, these processes are important, in particular, for the delivery of drugs, e.g., of doxorubicin, to the regions with a low degree of vascularization.…”

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

“…The Keplerate-type POMs and alike, being hydrophilic particles, are able to associate (form conjugates) in their external sphere with diverse substances, which include surfactants (SAs) of various nature [164][165][166][167][168][169][170][171], dyes, photosensitizers [109,110,[172][173][174], and polymers [174][175][176][177][178][179], mainly water-soluble ones. POMs functionalization makes it possible to selectively influence their hydrophilic and hydrophobic properties [110], create catalytic and photocatalytic systems with adjustable characteristics, as well as compositions for targeted delivery in biomedicine, controlled by an electric [179] or magnetic field [180,181]. The hydrophobized POMs acquire an ability to more actively interact with molecules of nonpolar substances and adsorb them [110].…”

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

“…Weaker, e.g., hydrogen, bonds also actively participate in the interaction of organic compounds with POMs [182]. The formation of POM associates with water-soluble nonionic polymers [174][175][176][177][178][179][183][184][185], including the biocompatible ones, makes it possible to create protective shells on the POM surface, similar to polyethylene glycol (PEG) layers, or to diblock copolymers on nanocapsules [186][187][188][189][190][191][192][193][194]. In a number of cases, the energy factor (interaction enthalpy) contributes to the formation of these associates.…”

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

See 2 more Smart Citations

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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“…Once the drug reaches the target tissue, it is released by factors such as temperature, pH and enzymatic activity [13,14]. In spite of modern methods based on the use of nanocarriers [15][16][17][18][19], traditional chemotherapy methods have many side effects [20,21].…”

Section: Introductionmentioning

confidence: 99%

A quantum chemical study on the magnetic nanocarrier-tirapazamine drug delivery system

Avarand¹,

Morsali²,

Heravi³

et al. 2021

Nanosystems: Phys. Chem. Math.

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Magnetic nanoparticles are among the most important carriers for the delivery of anticancer drugs. Four important noncovalent interactions between tirapazamine anticancer drug (TPZ) and magnetic nanoparticle Fe 6 (OH) 18 (H 2 O) 6 (MNP) have been examined by using density functional theory (DFT). Important interactions are those where the drug approaches the magnetic nanocarrier via NH 2 (MNP/TPZ1), NO (MNP/TPZ2-3) and intraring N-atom (MNP/TP4) functional groups. The negative values of binding energies and quantum molecular descriptor showed that these interactions contribute to the stability of the system. By increasing the temperature, TPZ can bond to MNP through NH 2 (NH 2 mechanism), NO (NO mechanisms) and intraring N-atom (N mechanism) functional groups. The activation parameters of four mechanisms were evaluated using quadratic synchronous transit method. Relative energies indicate that the product of the NH 2 mechanism is more stable but is produced more slowly (thermodynamic product). In contrast, the products of the NO mechanisms are kinetic products.

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“…Пористый сферический нанокластерный полиоксометаллат (ПОМ) с уникальной структурой кеплератного типа [1,2] , как и родственные кеплератные структуры, представляет интерес в различных областях, таких как биомедицинская отрасль [3][4][5]. Указывается на его применимость в катализе [6,7].…”

Section: Introductionunclassified

Influence of the Nanocluster {Mofe} Polyoxometalate on Oxidation of Iodide-Ions by Persulfate

Меньшиков¹,

Белозерова²,

Остроушко³

2020

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

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Изучены каталитические свойства нанокластерного железомолибденового полиоксометаллата {MoFe} в растворах при реализации окисления персульфатом йодид-ионов. Использована автоматизированная установка на базе спектрофотометрического метода анализа, управляемая компьютером. Сравнение литературных данных и кинетических данных окисления иодида персульфатом показывает, что кеплерат является гетерогенным катализатором. Эти данные позволяют предполагать нерадикальный механизм для разложения персульфата на поверхности молекул кластера на первой стадии реакции окисления иодида калия. Значение эффективной энергии активации процесса указывает на каталитическое воздействие {MoFe} на промежуточной стадии разложения пероксида водорода. Catalytic properties of the nanocluster iron-molybdenum polyoxometalate {MoFe} in solutions during the oxidation of iodide ions by persulfate have been studied. Automated installation based on spectrophotometric method of analysis controlled by computer was used. Comparison of literary data and kinetic datа on the oxidation of iodide with persulfate showed that keplerate {MoFe} is a heterogeneous catalyst. These data allowed to assume a non-radical mechanism for persulfate decomposition on the surface of cluster molecules at the first stage of the potassium iodide oxidation reaction. The value of the effective activation energy of the process indicates the catalytic effect of {MoFe} at the intermediate stage of the decomposition of the hydrogen peroxide.

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The use of nanocluster polyoxometalates in the bioactive substance delivery systems

Cited by 9 publications

References 276 publications

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

A quantum chemical study on the magnetic nanocarrier-tirapazamine drug delivery system

Influence of the Nanocluster {Mofe} Polyoxometalate on Oxidation of Iodide-Ions by Persulfate

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