The Use of Nanotechnology in Modern Pharmacotherapy

Ostróżka-Cieślik, Aneta; Sarecka-Hujar, Beata

doi:10.1016/b978-0-323-52725-5.00007-1

Cited by 24 publications

(21 citation statements)

References 174 publications

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“…The following types of NPs can be distinguished in relation to the material used: lipid-based (e.g., nanoliposomes, lipospheres, including solid lipid NPs (SLN) and nanostructured lipid carriers), polymeric-based (e.g., nanospheres, nanocapsules) or carbon-based (fullerenes, carbon dots, carbon nanotubes (CNT)). 6 Nanoliposomes are spherical structures up to 100-200 nm in size, with the walls formed by a lipid bilayer with an aqueous phase as a core of a vesicle. The structure of the liposomes/nanoliposomes, as well as methods of their preparation and division, are well-understood and have been described in previous studies.…”

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

“…The structure of the liposomes/nanoliposomes, as well as methods of their preparation and division, are well-understood and have been described in previous studies. 6 Nanoliposomes show a number of advantages, e.g., lack of toxicity and immunogenicity, full biodegradability and structural versatility as carriers. However, a number of disadvantages of liposomal carriers can be noted.…”

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

“…Studies demonstrated, among others, low stability, especially in the case of aquatic environment, high accumulation in the liver and spleen, difficulty in overcoming the blood-tissue barrier, oxidation of the lipid, hydrolysis of the ester moiety, or API release to the external phase. 6,15 Many studies have, therefore, been performed to modify the structure of liposomes sufficient to obtain the efficient transport of active substances. 15,16 Nanoliposomes can be often coated with polyethylene glycol (PEG), which may, among other things, affect the half-life of the drug-molecule-transporter conjugate in the blood.…”

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

“…16 Another spherical lipid-based particles are lipospheres with a size of up to 500 nm, in which 2 types can be distinguished: SLN and nanostructured lipid carriers (NLC). 6 The structure of SLN resembles the oil/water (o/w) emulsion, in which the liquid lipid has been replaced by a lipid solid at room temperature. 17 The biologically active compounds are arranged in an aqueous phase containing surfactants between the chains of the hydrophobic compounds.…”

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

“…5 The NPs can also be suspended in a liquid or embedded into a solid matrix. 6 The specificity of the nanopreparation is associated with a reduced dose or concentration of API. In addition, reduced adverse effects of API can also be observed.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases

Sarecka-Hujar¹,

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et al. 2020

Adv Clin Exp Med

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Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

Section: Characteristics Of Selected Drug Nanocarriersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases

Sarecka-Hujar¹,

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et al. 2020

Adv Clin Exp Med

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Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials

Dehnavi¹,

Zadeh

Harvey

et al. 2022

Advanced Materials

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The incorporation of nanotechnology in regenerative medicine is at the nexus of fundamental innovations and early‐stage breakthroughs, enabling exciting biomedical advances. One of the most exciting recent developments is the use of nanoscale constructs to influence the fate of cells, which are the basic building blocks of healthy function. Appropriate cell types can be effectively manipulated by direct cell reprogramming; a robust technique to manipulate cellular function and fate, underpinning burgeoning advances in drug delivery systems, regenerative medicine, and disease remodeling. Individual transcription factors, or combinations thereof, can be introduced into cells using both viral and nonviral delivery systems. Existing approaches have inherent limitations. Viral‐based tools include issues of viral integration into the genome of the cells, the propensity for uncontrollable silencing, reduced copy potential and cell specificity, and neutralization via the immune response. Current nonviral cell reprogramming tools generally suffer from inferior expression efficiency. Nanomaterials are increasingly being explored to address these challenges and improve the efficacy of both viral and nonviral delivery because of their unique properties such as small size and high surface area. This review presents the state‐of‐the‐art research in cell reprogramming, focused on recent breakthroughs in the deployment of nanomaterials as cell reprogramming delivery tools.

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Synthesis and Cyclooxygenase Enzyme Inhibitory Activity of Flurbiprofen Analogues: Simple Methodology of Their Nanoemulsion Systems

Önel

Saygili

2022

ChemistrySelect

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Most over-the-counter (OTC) and prescription NSAIDs have common side effects, especially gastrointestinal problems. Flurbiprofen, is an analogue of ibuprofen, that causes side effects and discomfort. This study was to synthesize flurbiprofen analogues, determine their NSAID activity using in vitro cyclooxygenase enzyme inhibitory assays and prepare their nanoemulsions. Six new flurbiprofen derivatives were synthesized via the reaction of acyl chloride (of flurbiprofen) and βamino alcohol, amino acid ester (or amino dicarboxylic acid ester). The masking of the free carboxylic acid functional group of flurbiprofen lowered the acidity by nearly two-fold. The compounds, tested for their cyclooxygenase (COX-1 and À 2) enzyme inhibitory activity, showed analogues 3 d and 3 f could be of interest due to relatively higher COX-2 enzyme inhibition. Nanoemulsions (NEs) of flurbiprofen analogues (3 d and 3 f) were developed using high energy emulsification technique and the results showed that the optimized nanoemulsions of 3 d presented a droplet size of 225 nm, polydispersity index of 0.568, and zeta potential of + 29.60 mV.

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The Use of Nanotechnology in Modern Pharmacotherapy

Cited by 24 publications

References 174 publications

Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases

Evaluation of the potential of nanoparticles containing active substances in selected chronic diseases

Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials

Synthesis and Cyclooxygenase Enzyme Inhibitory Activity of Flurbiprofen Analogues: Simple Methodology of Their Nanoemulsion Systems

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