2017
DOI: 10.1016/j.canlet.2017.09.050
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The use of natural compounds for the targeting and chemoprevention of ovarian cancer

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Cited by 64 publications
(58 citation statements)
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“…Therefore, CSC‐related molecular changes can enable the development of specific agents for the eradication of tumor‐maintaining CSCs. Natural products, such as EGCG, curcumin, resveratrol, sulforaphane, and withaferin‐A, can diminish the clinically devastating properties of CSCs . For example, curcumin and EGCG can inhibit breast CSCs through downregulating STAT3–NF‐κB signaling .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, CSC‐related molecular changes can enable the development of specific agents for the eradication of tumor‐maintaining CSCs. Natural products, such as EGCG, curcumin, resveratrol, sulforaphane, and withaferin‐A, can diminish the clinically devastating properties of CSCs . For example, curcumin and EGCG can inhibit breast CSCs through downregulating STAT3–NF‐κB signaling .…”
Section: Discussionmentioning
confidence: 99%
“…8 Natural compounds have aroused increasing attention in the eld of cancer and CSCs due to their high activity and low side effects. [9][10][11] Currently, about 60% of approved anticancer drugs come from unmodied natural products, their semisynthetic derivatives, or molecules synthesized based on natural products. 12,13 18b-glycyrrhetinic acid (GA, 1, Fig.…”
Section: Introductionmentioning
confidence: 99%
“…The potential mechanisms underlying platinum-based chemotherapy involve pharmacological, biochemical, apoptosis and microenvironment resistance (8). Emerging evidences have also indicated that autophagy may be involved in cell survival and chemoresistance mechanisms (9)(10)(11)(12). Macroautophagy (autophagy) is a conserved catabolic pathway in which cytosolic contents, such as damaged organelles, misfolded proteins and bacteria, are transported into lysosomes for degradation (13,14).…”
Section: Introductionmentioning
confidence: 99%