The Use of Natural Products in the Treatment of Sickle Cell Disease

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential

“…These substances may operate by reducing the body’s oxidative stress levels, a factor believed to intensify the severity of the illness [ 73 ]. Their ability to lower oxidative stress makes them a promising treatment option for sickle cell complications [ 42 , 74 ].…”

“…For example, significant components in vegetables, phenolics have promising impact on human health. As an illustration, the Carica papaya was employed as a substitute therapeutic agent for SCD [ 74 ]. Polar phenolic compounds viz.…”

“…The potent components found in medicinal plants and natural compounds, termed antisickling agents, abundant in aromatic amino acids, phenolic compounds, and antioxidants, serve as antioxidant therapy to alleviate the complexities of sickle cell anemia, exhibiting protective effects such as shielding against lipid peroxidation in red blood cells, enhancing glutathione levels (GSH), and diminishing levels of reactive oxygen species (ROS) [97]. Therefore, it was concluded that herbal medicines have substantial potential in the therapeutic management of sickle cell disease, with the possibility of addressing both the underlying causes and the symptoms of the condition [74]. [ [109][110][111] One promising example is niprisan, a plant-based medicine with antisickling properties.…”