The Use of Near Infrared Spectroscopy to Evaluate the Effect of Exercise on Peripheral Muscle Oxygenation in Patients with Lower Extremity Artery Disease: A Systematic Review

Cornelis, Nils; Chatzinikolaou, Panagiotis N.; Buys, Roselien; Fourneau, Inge; Claes, Jomme; Cornelissen, Véronique

doi:10.1016/j.ejvs.2021.02.008

Cited by 21 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is of interest to ascertain what underlying adaptations from exercise training enable improvements in MRO 2 , and in particular, whether these adaptations improve resting muscle MRO 2 . To date, direct blood flow measurements with optical diffuse correlation spectroscopy have provided evidence that exercise training increases the peak calf muscle blood flow reached during walking [16]; similar evidence is apparent from indirect time-to-minimum calf tissue oxygen saturation measurements with near-infrared spectroscopy [10,[17][18][19][20]. Improvements in oxygen delivery from increased blood flow can sustain higher MRO 2 levels during exercise.…”

Section: Introductionmentioning

confidence: 80%

“…Metabolites 2021, 11, 814 2 of 13 Claudication is triggered by limb ischemia that arises from large artery stenosis, vascular dysfunction, inflammation, and other factors [3,9]. Numerous investigators have studied the adaptive responses to exercise training in PAD patients that may delay the onset of limb ischemia [6][7][8][10][11][12][13]. One plausibly important adaptation mechanism is improved calf muscle oxygen metabolism [6,8,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease

Englund

Langham

et al. 2021

Metabolites

View full text Add to dashboard Cite

Exercise training can mitigate symptoms of claudication (walking-induced muscle pain) in patients with peripheral artery disease (PAD). One adaptive response enabling this improvement is enhanced muscle oxygen metabolism. To explore this issue, we used arterial-occlusion diffuse optical spectroscopy (AO-DOS) to measure the effects of exercise training on the metabolic rate of oxygen (MRO2) in resting calf muscle. Additionally, venous-occlusion DOS (VO-DOS) and frequency-domain DOS (FD-DOS) were used to measure muscle blood flow (F) and tissue oxygen saturation (StO2), and resting calf muscle oxygen extraction fraction (OEF) was calculated from MRO2, F, and blood hemoglobin. Lastly, the venous/arterial ratio (γ) of blood monitored by FD-DOS was calculated from OEF and StO2. PAD patients who experience claudication (n = 28) were randomly assigned to exercise and control groups. Patients in the exercise group received 3 months of supervised exercise training. Optical measurements were obtained at baseline and at 3 months in both groups. Resting MRO2, OEF, and F, respectively, increased by 30% (12%, 44%) (p < 0.001), 17% (6%, 45%) (p = 0.003), and 7% (0%, 16%) (p = 0.11), after exercise training (median (interquartile range)). The pre-exercise γ was 0.76 (0.61, 0.89); it decreased by 12% (35%, 6%) after exercise training (p = 0.011). Improvement in exercise performance was associated with a correlative increase in resting OEF (R = 0.45, p = 0.02).

show abstract

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease

Englund

Langham

et al. 2021

Metabolites

View full text Add to dashboard Cite

show abstract

“…Last, no control group was studied, but patients were their own control (comparison between postexercise and pre-exercise values). Future studies might be needed to investigate the relationship of biomarkers with new indices of clinical severity of exercise-induced ischemia, such as near-IR spectroscopy, contrast ultrasound, MRI, or muscle scintigraphy ( Lindner et al, 2008 ; Potthast et al, 2009 ; Pande et al, 2011 ; Boezeman et al, 2016 ; Cornelis et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Exercise-Induced Plasma Metabolomic Profiles in Patients With Peripheral Arterial Disease

et al. 2021

View full text Add to dashboard Cite

Aim: A better knowledge of the biological consequences in the blood of these exercise-induced ischemic events in lower extremity artery disease (LEAD) may improve the prospects of disease management. We explored the preminus postexercise metabolomic difference in 39 patients with LEAD referred for a treadmill oximetry test [transcutaneous oximetry (TcPO2)].Methods: Ischemia was estimated through the sum of decrease from rest of oxygen pressure (DROPs) (limb TcPO2 changes minus chest TcPO2 changes) at buttocks, thighs, and calves regions. Targeted metabolomic analyses measuring 188 metabolites were performed on a few microliters blood samples taken at the earlobe at rest and 3 min after exercise.Results: Maximum walking distance (MWD) was 290 m (120–652 m) and ankle brachial index (ABI) was 0.67 ± 0.17. Supervised paired partial least squares discriminant analysis based on 23,345 models showed good predictive performance for test sets with a median area under the receiver operating characteristic (AUROC) curve value of 0.99 and a p-value of 0.00049. The best discriminant metabolites contributing to the model included a subset of 71 (47%) of the 150 accurately measured metabolites in the plasma, comprising 3 acylcarnitines, 3 amino acids, 5 biogenic amines, 9 sphingomyelin, 7 lysophosphatidylcholines, and 44 phosphatidylcholines. In addition, 16 of these metabolites were found to correlate with one or more severity scores of the LEAD.Conclusion: Our results provide new insights into the biological changes that accompany exercise in LEAD and contribute to a better understanding of walking impairment pathophysiology in LEAD, highlighting new candidate biomarkers.

show abstract

“…Subsequently, intracellular acidosis as a result of ischemia is corrected by an increase of calcium release in response to reperfusion. This causes an opening of mitochondrial permeability transition pores and a sudden change in mitochondrial membrane permeability, resulting in a loss of membrane potential and release of pro-apoptotic factors and cell death [9,27,[30][31][32]. Ischemia-reperfusion events impair mitochondrial and cellular integrity by increasing free radical production in combination with dysfunction of the complexes of the respiratory system, which results in lipid peroxidation, protein oxidation, and mitochondrial DNA damage [9].…”

Section: Effects Of Ischemia Reperfusion Injury On Muscle Mitochondriamentioning

confidence: 99%

“…Near-infrared spectroscopy (NIRS) enables the in-vivo visualization of the mismatch between oxygen demand and oxygen supply, especially during exercise, and distally of flow-limiting arteriosclerotic lesions [32]. NIRS uses near-infrared light with different wavelengths (700-900 nm) to transmit photons to the muscle of interest non-invasively as the probes are positioned on the skin of the respective region [33].…”

Section: Near-infrared Spectroscopy (Nirs)mentioning

confidence: 99%

The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies

Gratl

Wipper

Frese

et al. 2021

IJMS

View full text Add to dashboard Cite

Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, 31P magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression.

show abstract

The Use of Near Infrared Spectroscopy to Evaluate the Effect of Exercise on Peripheral Muscle Oxygenation in Patients with Lower Extremity Artery Disease: A Systematic Review

Cited by 21 publications

References 38 publications

Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease

Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease

Exercise-Induced Plasma Metabolomic Profiles in Patients With Peripheral Arterial Disease

The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies

Contact Info

Product

Resources

About