-Before the first symptoms, high blood pressure (HBP or hypertension) damages human body for years. Statistically half of the untreated hypertension results to fatal heart attack. For years, there have been different types of blood pressure measurement techniques proposed. Despite of not having pin-point accuracy, non-invasive blood pressure (BP) measurement is preferred to invasive measurement techniques due to the facts like avoid bleeding, infections and for simplicity as well. In this paper, a non-invasive in-vivo technique has been described to calculate pulse rate and systolic and diastolic pressure for human body. An image sensor with a novel single carrier modulation photo-detector (SMPD) has been used to capture vein or artery images. Through some video and image processing, pulse rate has been determined with significant accuracy. Some further numerical analysis have been done to calculate systolic and diastolic pressure.