The Use of Neutral Red as a Peroperative Test of Vagal Innervation

Nundy, Samiran; Jh, Baron

doi:10.1080/00365521.1975.12097059

Cited by 5 publications

(1 citation statement)

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“…However, aminopyrine was known to be too toxic in humans, except in small doses using the |4C label [10], and neutral red has been introduced as a replacement [11,12]. Neutral red had previously been advocated as a perioperative test for the completeness of vagotomy [13] and in conjunction with 2-deoxy-D-glucose as a pre-and postoperative test to investigate the completeness of vagal section [14]. The use of neutral red clearance to estimate gastric mucosal blood flow in humans has added a new dimension to the standard gastric function test, but it would be too simple to assume that clearance is synonymous with blood flow.…”

Section: Methods and Their Limitationsmentioning

confidence: 99%

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

et al. 1982

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Gastric mucosal blood flow (neutral red clearance, NRC) and acid secretion were measured before and after highly selective vagotomy (HSV). Eleven patients with duodenal ulcer were studied before and 12–21 days after HSV. Eight volunteers were also studied using the histamine‐H2‐receptor antagonists cimetidine and ranitidine. Basal secretion was collected for 40–50 minutes and pentagastrin was given in increasing doses each for 40 minutes. Data were analyzed using Wilcoxon's signed‐ranks test for paired samples and an analysis of covariance. Basal NRC was similar both for patients and for volunteers and was unaffected by HSV. There was a linear correlation between NRC and acid output. The patients with duodenal ulcer had a lower ratio of NRC to acid during pentagastrin stimulation than was found in normal subjects, but the regression line after HSV was comparable to that found for the volunteers. Although stimulated acid output was reduced by HSV, NRC was significantly higher after HSV than before. The 2 histamine‐H2‐receptor antagonists reduced both NRC and acid to a similar extent, and this could not be overcome by increasing the dose of pentagastrin. These results indicate that mucosal blood flow and acid secretion may not be unconditionally linked, although a linear relationship was always found. HSV produces an effect on blood flow that is not linked to the reduction in acid output.

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