The Use of Palladium on Magnetic Support as Catalyst for Suzuki–Miyaura Cross-Coupling Reactions

Abstract

Abstract:The development of new solid supports for palladium has received a lot of interest lately. These catalysts have been tested in a range of cross-coupling reactions, such as Suzuki-Miyaura, Mizoroki-Heck, and Sonogashira cross-coupling reactions, with good outcomes. Attaching the catalyst to a solid support simplifies the operations required in order to isolate and recycle the catalyst after a reaction has completed. Palladium on solid supports made of magnetic materials is particularly interesting since such catalysts can be removed very simply by utilizing an external magnet, which withholds the catalyst in the reaction vessel. This review will showcase some of the latest magnetic solid supports for palladium and highlight these catalysts' performance in Suzuki-Miyaura cross-coupling reactions.

Highly efficient and recyclable water-soluble fullerene-supported PdCl2 nanocatalyst in Suzuki–Miyaura cross-coupling reaction

“…[1][2][3][4][5][6] It is applied for organic functional materials and extensively employed in the synthesis of herbicides, pharmaceuticals, and natural products as biaryl motifs. [7][8][9][10][11] The catalyst used in the Suzuki-Miyaura cross-coupling reaction is vital for this reaction, and the search for a suitable catalyst is the latest and most challenging research area.…”

Current Applications of Suzuki–Miyaura Coupling Reaction in The Total Synthesis of Natural Products: An update

“…This reaction has found several applications in organic synthesis due to its versatility, high stability and low toxicity of the required starting materials which mostly commercially available or readily accessible. In addition, the introduction of various substrates of organoborane reagents is practically simple and the resultants often remain unaffected throughout subsequent transformations in the presence of immensely functionalized biomolecules, molecular oxygen, water and can frequently be performed under ambient reaction conditions …”

“…In addition, the introduction of various substrates of organoborane reagents is practically simple and the resultants often remain unaffected throughout subsequent transformations in the presence of immensely functionalized biomolecules, molecular oxygen, water and can frequently be performed under ambient reaction conditions. [12][13][14][15][16][17][18][19] Akira Suzuki shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for his endeavors in the innovation and development of Pd-catalyzed cross-coupling reaction, which obviously Abbreviations: 9-BBN, 9-Borabicyclo[3.3.1]nonane; Db a, dibenzylideneacetone; DME, 1,2-dimethoxyethane; dppf, 1,1'-bis(diphenylphosphanyl)ferrocene; Dppf, 1,1'-bis(diphenylphosphino)ferrocene; DTBPF, 1,1′-bis(di-tert-butylphosphino)ferrocene; MIDA-ester, N-methyliminodiacetic ester; MOM, methoxymethyl; OTf, trifluoromethanesulfonate; PBDs, pyrrolobenzodiazepines; Pd(PCy) 3 , Palladium(II)bis(triphenylphosphine) dichloride; RuPhos, 2-Dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl; SMCR, Suzuki-Miyaura coupling reaction; SPhos, 2-dicyclohexylphosphino-2'-6'-dimethoxybiphenyl; TBAF, tetra-n-butylammonium fluoride; TBDPS, tert-butyldiphenylsilyl; TBS, tert-butyl(dimethyl)silyl; TBSOTf, tert-Butyldimethylsilyl trifluoromethanesulfonate; TIPS, N-trisisopropylsilyl; TlOEt, thallium(I) ethoxide; TMPMgCl·LiCl; TMP, 2,2,6,6-tetramethylpiperidinyl; XPhos, 2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl confirms and even coins the significance of (SMCR) in the art of organic synthesis. [20] The first stereoselective version of the SMCR was achieved and reported by during the total synthesis of vancomycin which is a peptidebased antibiotic drug.…”

Suzuki–Miyaura coupling reaction in water in the presence of robust palladium immobilized on modified magnetic Fe3O4 nanoparticles as a recoverable catalyst

“…As is known, palladium is a precious metal and is useful in many organic transformations, especially in Suzuki coupling. Biaryl compounds are of high importance and have many applications, so scientists are still seeking for new ways to produce them in easier and affordable ways …”