The use of phase angle in patients with digestive and liver diseases

Casirati, Amanda; Crotti, Silvia; Raffaele, Alessandro; Caccialanza, Riccardo; Cereda, Emanuele

doi:10.1007/s11154-023-09785-6

Cited by 10 publications

(6 citation statements)

References 82 publications

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“…PA is an indicator derived from the bioelectrical impedance principle to assist in diagnosing nutritional status, which can speci cally re ects the state of structural integrity and functional impairment of human cell membranes (Casirati A et al,2023). Reduced PA can be diagnosed when PA is below 5.0° in males and 4.6° in females (Girma T et al,2017).…”

Section: Explanation Of Ecw/tbw Univariate Analysis Resultsmentioning

confidence: 99%

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

heling,

panpan,

jie

et al. 2024

Preprint

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Objective This study aims to examine the factors contributing to the increase in extracellular water to total body water ratio (ECW/TBW) among tumor patients without visible edema, and to offer insights into the diagnosis and prompt management of early water retention in such patients. Methods A cohort of 274 tumor patients admitted to Anqing First People's Hospital, affiliated with Anhui Medical University between December 2020 and December 2022, were selected, excluding those with clinically observable edema. General clinical data, main laboratory test outcomes, and body composition indices were gathered. Valuable variables were identified for linear regression analysis using ECW/TBW, based on professional knowledge and univariate analysis results. Results Age, gender, hemoglobin, serum sodium, serum potassium, and phase angle (PA) were determined as independent influencing factors for elevated ECW/TBW. ECW/TBW increased with age (partial regression coefficient B=0.009, P=0.001), was higher in males than in females (B=-0.349, P<0.001), and was negatively affected by hemoglobin (Hgb) (B=-0.003, P=0.039). Serum sodium had a positive influence on ECW/TBW (B=0.019, P=0.011), while serum potassium exhibited a negative effect (B=-0.180, P=0.001). PA was the most influential factor among all independent variables affecting ECW/TBW (B=-1.006, P<0.001). Nonetheless, Performance Status (PS) score, Patient-Generated Subjective Global Assessment (PG-SGA) score, tumor stage, prealbumin, albumin, and body fat percentage were not identified as independent factors influencing elevated ECW/TBW. Conclusion The early factors influencing water retention in tumor patients primarily stem from abnormal cell membrane function, but are also impacted by age, gender, anemia, and electrolyte levels. Timely body composition testing can assist in subsequent intervention decision-making.

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Section: Explanation Of Ecw/tbw Univariate Analysis Resultsmentioning

confidence: 99%

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

heling,

panpan,

jie

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…PA is an indicator derived from the bioelectrical impedance principle to assist in the diagnosis of nutritional status, which can speci cally respond to the state of structural integrity and functional impairment of human cell membranes [15]. PA below 5.0° in male and 4.6° in female can be diagnosed as reduced PA [16].…”

Section: Explanation Of Ecw/tbw Univariate Analysis Resultsmentioning

confidence: 99%

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

heling

panpan

jie

et al. 2023

Preprint

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Objective To analyze the factors influencing the increase of extracellular water/total body water (ECW/TBW) in tumor patients lacking edema signs, and to provide reference for the diagnosis and timely management of early water retention in tumor patients. Methods 274 tumor patients admitted to Anqing First People's Hospital affiliated to Anhui Medical University during 2020.12-2022.12 were selected, excluding clinically observable edema. General clinical data, main laboratory test results and body composition indexes were collected,and the valuable variables were screened for linear regression analysis with ECW/TBW based on professional knowledge and univariate analysis results. Results Age, gender, hemoglobin, serum sodium,serum potassium and phase angle (PA) were independent influencing factors for elevated ECW/TBW. ECW/TBW increased with increasing age (partial regression coefficient B=0.009, P=0.001), ECW/TBW was higher in males than in females (B=-0.349, P<0.001), and hemoglobin (Hgb) negatively affected ECW/TBW (B=-0.003, P=0.039). Blood sodium positively affected ECW/TBW (B=0.019, P=0.011), while blood potassium had a negative effect (B=-0.180, P=0.001). PA was the factor with the greatest influence on ECW/TBW of all independent variables (B=-1.006, P<0.001). However, Performance Status (PS) score, Patient-Generated Subjective Global Assessment(PG-SGA) score, tumor stage, prealbumin, albumin, and body fat percentage were not independent influences for elevated ECW/TBW. Conclusion The early influencing factors of water retention in tumor patients are mainly due to the abnormal function of cell membrane, but also affected by age, gender, anemia and electrolyte, and timely body composition testing can help in the next intervention decision making.

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“…Application in clinical practice on a prospective basis with serial measurements would allow monitoring of interventions and response to more individualized treatments and improve outcomes. In future research, efforts to harmonize measurements between different devices should be considered in order to obtain a more objective interpretation of the output data, with standardized phase angle values (SPhA) [41].…”

Section: Digestive and Liver Diseasesmentioning

confidence: 99%

“…The dehydratedmalnourished patient with CKD has depleted body fat with decreased ECW and ICW; PhA is near normal and vector length is elongated. It also is important to recognize that individuals with the same PhA can have different hydration status based on vector position on the R/Xc graph [41,66].…”

Section: Chronic Kidney Disease (Ckd)mentioning

confidence: 99%

Future lines of research on phase angle: Strengths and limitations

Guerrero

García-García

Talluri³

et al. 2023

Rev Endocr Metab Disord

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Bioelectrical impedance analysis (BIA) is the most widely used technique in body composition analysis. When we focus the use of phase sensitive BIA on its raw parameters Resistance (R), Reactance (Xc) and Phase Angle (PhA), we eliminate the bias of using predictive equations based on reference models. In particular PhA, have demonstrated their prognostic utility in multiple aspects of health and disease. In recent years, as a strong association between prognostic and diagnostic factors has been observed, scientific interest in the utility of PhA has increased. In the different fields of knowledge in biomedical research, there are different ways of assessing the impact of a scientific-technical aspect such as PhA. Single frequency with phase detection bioimpedance analysis (SF-BIA) using a 50 kHz single frequency device and tetrapolar wrist-ankle electrode placement is the most widely used bioimpedance approach for characterization of whole-body composition. However, the incorporation of vector representation of raw bioelectrical parameters and direct mathematical calculations without the need for regression equations for the analysis of body compartments has been one of the most important aspects for the development of research in this area. These results provide new evidence for the validity of phase-sensitive bioelectrical measurements as biomarkers of fluid and nutritional status. To enable the development of clinical research that provides consistent results, it is essential to establish appropriate standardization of PhA measurement techniques. Standardization of test protocols will facilitate the diagnosis and assessment of the risk associated with reduced PhA and the evaluation of changes in response to therapeutic interventions. In this paper, we describe and overview the value of PhA in biomedical research, technical and instrumental aspects of PhA research, analysis of Areas of clinical research (cancer patients, digestive and liver diseases, critical and surgical patients, Respiratory, infectious, and COVID-19, obesity and metabolic diseases, Heart and kidney failure, Malnutrition and sarcopenia), characterisation of the different research outcomes, Morphofunctional assessment in disease-related malnutrition and other metabolic disorders: validation of PhA with reference clinical practice techniques, strengths and limitations. Based on the detailed study of the measurement technique, some of the key issues to be considered in future PhA research. On the other hand, it is important to assess the clinical conditions and the phenotype of the patients, as well as to establish a disease-specific clinical profile. The appropriate selection of the most critical outcomes is another fundamental aspect of research.

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The use of phase angle in patients with digestive and liver diseases

Cited by 10 publications

References 82 publications

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

Future lines of research on phase angle: Strengths and limitations

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