The use of photodynamic therapy as adjuvant therapy to surgery in recurrent malignant tumors of the paranasal sinuses

Caesar, L.; Doeveren, T.E.M. van; Tan, I. Bing; Dilci, Alper; Veen, R.L.P. van; Karakullukçu, Barış

doi:10.1016/j.pdpdt.2015.06.001

Cited by 33 publications

(29 citation statements)

References 24 publications

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“…Photodynamic therapy (PDT), a form of light‐based medical treatment, has been developed as salvage or palliative treatment for a wide range of tumors, such as gastrointestinal, breast, skin, and head and neck tumors . PDT has attracted considerable attention because it is minimally invasive and has low mutagenic potential and low systemic toxicity .…”

mentioning

confidence: 99%

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

Huang

Liu

et al. 2018

Cytometry Pt A

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Photodynamic therapy (PDT) has been developed as salvage or palliative treatment for a wide range of tumors. The principle underlying this therapy is the generation of reactive oxygen species through two types of photochemical pathways. As compared with the type II pathway, the type I pathway offers a higher oxidizing ability for photosensitive residues such as tryptophan, lower oxygen dependency, and deeper tissue penetration ability. In this review, we focus on the enhancement of the type I pathway in the near infrared (NIR) optical therapeutic window of wavelength 700-1,100 nm by using antennae-fullerene complexes. When photo-induced electron transfer occurs from antennas to fullerene, the pathway switches from type II to type I. Enhancing the type I pathway leads to less oxygen dependency and stronger capacity for tryptophan oxidation. Then, antennae that transfer long-wavelength light (e.g., NIR light) energy to fullerene via photo-induced energy and/or electron transfer have the ability to affect deep-seated tumors. On the basis of theories on photo-induced energy/electron transfer in other fields such as solar cells, here, we summarize the mechanism by which the switch from the type II to type I pathway occurs in antenna-fullerene-based PDT.

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mentioning

confidence: 99%

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

Huang

Liu

et al. 2018

Cytometry Pt A

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“…Resection with adequate margins may be limited by surrounding essential structures, reconstruction capabilities, high risk of morbidity, or dysfunction . Because there are no limitations to apply PDT after conventional treatment modalities, there is a potential benefit of PDT as adjuvant treatment . The role of adjuvant PDT intra‐ or postoperatively has been reported with promising results but with restricted patient numbers and a large variability in tumor location .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies demonstrated a clinical added value of PDT as an adjuvant treatment to salvage surgery . The primary indication for adjuvant PDT is macroscopic or microscopic close or positive surgical resection margins, when other mainstay adjuvant treatments are contraindicated due to an unacceptable risk associated with their potential toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…The primary indication for adjuvant PDT is macroscopic or microscopic close or positive surgical resection margins, when other mainstay adjuvant treatments are contraindicated due to an unacceptable risk associated with their potential toxicity. The studies concluded that adjuvant PDT after surgery is safe and can result in good oncological and functional outcomes . However, adjuvant PDT after surgery with tumor positive resection margins has only been described in small patient cohorts, describing various tumor types, photosensitizers, and time intervals between surgery and PDT, and thereby limiting the scientific evidence for further clinical application.…”

Section: Introductionmentioning

confidence: 99%

“…However, adjuvant PDT after surgery with tumor positive resection margins has only been described in small patient cohorts, describing various tumor types, photosensitizers, and time intervals between surgery and PDT, and thereby limiting the scientific evidence for further clinical application. In particular, the optimal time interval between surgery and PDT has not been clarified …”

Section: Introductionmentioning

confidence: 99%

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Adjuvant photodynamic therapy in head and neck cancer after tumor‐positive resection margins

et al. 2017

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An Ethacrynic Acid‐Brominated BODIPY Photosensitizer (EA‐BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor‐Targeted Photodynamic Therapy

Won

Koo

et al. 2020

Angewandte Chemie

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Despite being a clinically approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors since lower levels of cytotoxic reactive oxygen species (ROS) are generated in regions of low oxygen tension. Glutathione‐pi (GST‐pi) is a key enzyme that militates against ROS‐mediated apoptosis. We report herein a new construct, EA‐BPS, that contains both a brominated BODIPY photosensitizer (BPS) and an ethacrynic acid (EA) GST‐pi inhibitor. Photoirradiation of EA‐BPS induces a synergistic antitumor effect that results from the combination of ROS production and GST‐pi inhibition. Relative to BPS alone, an enhanced cell‐killing effect is seen under hypoxic conditions both in vitro and in vivo. We conclude that by making better use of the available oxygen in tumor environments, improved therapeutic PDT outcomes should be achievable even under hypoxic conditions.

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The use of photodynamic therapy as adjuvant therapy to surgery in recurrent malignant tumors of the paranasal sinuses

Cited by 33 publications

References 24 publications

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

Enhancing Type I Photochemistry in Photodynamic Therapy Under Near Infrared Light by Using Antennae–Fullerene Complexes

Adjuvant photodynamic therapy in head and neck cancer after tumor‐positive resection margins

An Ethacrynic Acid‐Brominated BODIPY Photosensitizer (EA‐BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor‐Targeted Photodynamic Therapy

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