The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Ezuruike, Udoamaka; Prieto, José M.

doi:10.1016/j.jep.2014.05.055

Cited by 334 publications

(224 citation statements)

References 623 publications

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“…The most active non-polar fractions of A. camperi offered bioactive benzoic acid derivatives including 2-hydroxy-benzoic acid ethyl ester (ethyl salicylate) and 2-hydroxy-benzoic acid phenyl methyl ester (benzyl salicylate). Benzoic acid and its derivatives were reported to have antioxidant and anti-diabetic properties [21]. A study undertaken clarified the carboxyl group as being essential to the salicylate structural requirements for hypoglycemic activity [22].…”

Section: Gc-ms Analysis Of Fractionsmentioning

confidence: 99%

In Vitro Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in Meriandra dianthera, Aloe camperi and a Polyherb

Sium¹,

Kareru²,

Kiage-Mokua³

et al. 2017

AJPS

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This paper reports the in vitro anti-diabetic profile of certain medicinal plants traditionally used in Eritrea for the management of type 2 diabetes. The crude methanolic extracts and fractions of Meriandra dianthera, Aloe camperi, a Polyherb and their fractions were investigated. The in vitro screening of the crude extracts has generally elicited a dose dependent α-glucosidase and α-amylase inhibition activities. M. dianthera displayed the highest α-glucosidase inhibitory activity (IC 50 : 0.074 ± 0.032 mg/mL) at the highest concentration tested (0.800 mg/mL) relative to A. camperi, the Polyherb and Acarbose (IC 50 : 0.37 ± 0.052, 0.56 ± 0.024 and 0.55 ± 0.029 respectively). The α-glucosidase inhibition activities of A. camperi and M. dianthera, except for the Polyherb and Acarbose, were significantly different (P < 0.05) at various ranges of concentrations (0.025 -0.800 mg/mL). The percentage α-amylase inhibitions of M. dianthera, A. camperi, the Polyherb and Acarbose, at the highest concentrations (0.800 mg/mL), were 78.3%, 15.9%, 16.4%, and 82.9% respectively. A. camperi and the Polyherb displayed lower α-amylase inhibitory activities (IC 50 :1.72 ± 0.06 and 2.57 ± 0.07 mg/mL respectively) compared to Acarbose and M. dianthera (IC 50 : 0.31 ± 0.01 and 0.43 ± 0.02 mg/mL respectively). For the α-amylase inhibition activity, even at lower concentrations (0.025 mg/mL), there were statistically significant differences (P < 0.01) among the values generated for all the extracts. The in vitro anti-diabetic screening of the fractions, at 0.800 mg/ml, displayed characteristic enzyme inhibition activities.How to cite this paper: Sium, M., Kareru, P., Kiage-Mokua, B., Sood, K., Langley, J. 534Generally, the non-polar fractions showed higher enzyme inhibitory activities compared to the polar fractions. The most bioactive non-polar fractions, thus, were subjected to GC-MS analysis and presented various essential oils, fatty acid methyl esters (FAMEs) and benzoic acid derivatives in those plants.

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Section: Gc-ms Analysis Of Fractionsmentioning

confidence: 99%

In Vitro Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in Meriandra dianthera, Aloe camperi and a Polyherb

Sium¹,

Kareru²,

Kiage-Mokua³

et al. 2017

AJPS

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“…Insulin resistance results in decreased glucose uptake in striated muscles in combination with reduced glycolysis and fatty acid oxidation in the liver, leading to a series of modifications in the insulin signaling pathway, which attenuates signal transduction [8][9]. The mechanisms leading to the development of T2D have not been fully elucidated to date, but it is known that there are risk factors for developing the disease such as advanced age, obesity, poor eating habits, and a sedentary lifestyle [10]. After a period of compensatory hyperinsulinemia due to insulin resistance, the β-cells gradually lose their ability to meet the demands for the hormone in the body, resulting in a progression to hyperglycemia, which is characteristic of T2D.…”

Section: Introductionmentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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“…The leaf extract has also been shown to enhance hepatic glutathione restoration [23]. Ethnobotanical surveys indicated that stem bark, leaves, and root extracts of these medicinal plants have been used for the treatments of various diseases in Nigeria [16,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Content and In vitro Diphenylpicrylhydrazyl Free Radical Scavenging Activity of Selected Medicinal Plants

Muhammad¹,

Abubakar²,

Rabiu³

et al. 2018

J Intercult Ethnopharmacol

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Background/Aim: The medicinal plants and their derivatives have long been recognized as important sources of antioxidants in the prevention and treatment of various diseases. This study investigated phytochemicals, antioxidant content, and in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activities of methanolic and aqueous leaves extracts of Anogeissus leiocarpus, Ipomoea asarifolia, Bauhinia rufescens, Guiera. Senegalensis, and Moringa oleifera. Materials and Methods:The extracts were subjected to qualitative phytochemical analysis to identify the bioactive constituents in each plant. Total phenolics and proanthocyanidin contents were determined using Folin-Ciocalteu and vanillin-methanol assays while antioxidant free scavenging activity was estimated using DPPH assay. Results: The phytochemical screening revealed the presence of alkaloids, flavonoids, and tannins in all the five plants investigated. The total phenolic and proanthocyanidin contents of methanolic extracts were significantly higher (p < 0.05) as compared with aqueous extracts. DPPH-free radical scavenging activity of methanolic extracts of A. leiocarpus and M. oleifera was similar to vitamin C. In vitro DPPH radical scavenging activity of methanolic extracts of A. leiocarpus and M. oleifera were better as compared with B. refescens, I. asarifolia, G. senegalensis, and aqueous extracts. The antioxidant activities of both extracts were in a dose-dependent manner. Furthermore, the lower IC 50 of methanolic extracts of A. leiocarpus, B. refescens, and M. oleifera correlated with strong scavenging activities of these plants. Conclusion:This study demonstrated the antioxidant content and DPPH-free radical scavenging activities of five medicinal plants. Thus, the study underscored these plants as potential sources of natural antioxidants that can be explored for the treatment of oxidant-related diseases.

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The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Cited by 334 publications

References 623 publications

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Antioxidant Content and In vitro Diphenylpicrylhydrazyl Free Radical Scavenging Activity of Selected Medicinal Plants

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The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations

Cited by 334 publications

References 623 publications

&lt;i&gt;In Vitro&lt;/i&gt; Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in &lt;i&gt;Meriandra dianthera, Aloe camperi&lt;/i&gt; and a Polyherb

&lt;i&gt;In Vitro&lt;/i&gt; Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in &lt;i&gt;Meriandra dianthera, Aloe camperi&lt;/i&gt; and a Polyherb

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Antioxidant Content and In vitro Diphenylpicrylhydrazyl Free Radical Scavenging Activity of Selected Medicinal Plants

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Product

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<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb

<i>In Vitro</i> Anti-Diabetic Activities and Phytochemical Analysis of Bioactive Fractions Present in <i>Meriandra dianthera, Aloe camperi</i> and a Polyherb