The use of platelet-rich plasma in plastic surgery: A systematic review

Sommeling, Casper; Heyneman, Alexander; Hoeksema, Henk; Verbelen, Jozef; Stillaert, Filip; Monstrey, Stan

doi:10.1016/j.bjps.2012.11.009

Cited by 189 publications

(158 citation statements)

References 43 publications

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“…O PRP é obtido por meio da centrifugação do sangue autógeno, que resulta em maior concentração de plaquetas em menor volume de plasma (Pagliosa & Alves 2007, Sommeling et al 2013. A comprovação da eficácia do uso do plasma rico em plaquetas já foi demostrada em vários estudos (Bauer et al 2009, Silva et al 2011, Vendruscolo et al 2012, Garcez et al 2013) e ainda pesquisadores buscam o conhecimento da eficácia dos efeitos biológicos do PRP quando aplicado em tecidos moles, osso e tegumento (Anitua 1999).…”

Section: Introductionunclassified

Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus)

et al. 2016

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Wounds of large tracts with loss of tissue viability and delayed healing by secondary intention are cases where it is necessary the use of reconstructive surgical techniques. The platelet rich plasma (PRP) is a product with a higher platelet concentration, adjuvant in the healing process of reconstructive surgeries, assisting in the processes of hemostasis and stimulation of angiogenesis. Thus, a study was devised to assess the efficacy of the gel produced from the platelet rich plasma (PRP) in the forward axial flaps thoracodorsal pattern in rabbits to evaluate the ability to promote the integration of the flap the recipient bed. We used 30 white rabbits New Zealand, separated into two groups of 15 animals, comprising the platelet rich plasma groups (GPRP), in which we used the gel before the synthesis of the surgical wound , and control (CG), in which only saline was used. To obtain the PRP, the blood was collected from the animals, was determined and the platelet count before preparation of the gel. At the beginning and end of the experiment the animals were weighed for analysis of average weight gain. After surgery began macroscopic in the 3rd, 7th and 14th day reviews, and we assessed the presence or absence of exudate, skin integrity, edema, redness and necrosis. After this step, yielded the material for the manufacture of surgical wound, followed by microscopic histological slides. We evaluated vascular proliferation, presence of polymorphonuclear and mononuclear cells, fibroblast proliferation, collagen deposition, reepithelialization and hemorrhage. The data were subjected to statistical analysis (Student t test, t paired, and Kruskal Wallis test, and p<0.05). The average weight gain was not significant between the groups; platelet concentration in the final sample of PRP was significantly higher when compared with the original; exudate and necrosis were significantly higher in the control group compared to PRP group, vascular proliferation and reepithelialization were significantly greater in PRP group, whereas the presence of mononuclear cells, polymorphonuclear cells, proliferation of fibroblasts, collagen and hemorrhage were not significant between groups. Obtained on the third day, as the difference significantly greater exudate variable in the control group compared to the PRP group; on 1 Recebido em 14 de fevereiro de 2015.Aceito para publicação em 22 de setembro de 2015.

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Section: Introductionunclassified

Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus)

et al. 2016

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“…PRP has been demonstrated to be effective in bone regeneration, wound healing, and improvement of musculoskeletal sports injuries. [9][10][11][12][13][14][15] Recently, clinicians extended the scope of PRP therapy to soft tissue augmentation by combining PRP with fat grafting. Although some successful clinical results were reported, 16,17 evidence supporting the application of PRP combined with fat grafts in soft tissue augmentation remains limited, as only a few basic research and preclinical studies in small animals have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Application of Platelet-Rich Plasma and Platelet-Rich Fibrin in Fat Grafting: Basic Science and Literature Review

Marra

2014

Tissue Engineering Part B: Reviews

131

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Due to the natural properties of fat, fat grafting remains a popular procedure for soft tissue volume augmentation and reconstruction. However, clinical outcome varies and is technique dependent. Platelet-rich plasma (PRP) contains a-granules, from which multiple growth factors such as platelet-derived growth factor, transforming growth factor-b, vascular endothelial growth factor, and epidermal growth factor can be released after activation. In recent years, the scope of PRP therapies has extended from bone regeneration, wound healing, and healing of musculoskeletal injuries, to enhancement of fat graft survival. In this review, we focus on the definition of PRP, the different PRP preparation and activation methods, and growth factor concentrations. In addition, we discuss possible mechanisms for the role of PRP in fat grafting by reviewing in vitro studies with adipose-derived stem cells, preadipocytes, and adipocytes, and preclinical and clinical research. We also review platelet-rich fibrin, a so-called second generation PRP, and its slow-releasing biology and effects on fat grafts compared to PRP in both animal and clinical research. Finally, we provide a general foundation on which to critically evaluate earlier studies, discuss the limitations of previous research, and direct plans for future experiments to improve the optimal effects of PRP in fat grafting.

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“…Although the efficacy of PRP has been investigated in wound healing [12][13][14][15] , its effects on TMP healing have not yet been investigated in acute TMPs. In the literature, the only study on the effect of PRP on TMP closure is that reported by El-Anwar et al [16] , wherein they studied 64 patients with chronic TMPs who had undergone postauricular myringoplasty with underlay graft using conchal perichondrial graft.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet-rich plasma is a concentration of autologous platelets which release polypeptides, including PDGF, TGFb1, VEGF, and EGF, each of which have different roles in wound healing, immune reactions, angiogenesis [12] , and bone regeneration [17,18] . There have been human studies to report that PRP has a positive effect on wound healing [12][13][14][15] .…”

Section: Discussionmentioning

confidence: 99%

“…There have been human studies to report that PRP has a positive effect on wound healing [12][13][14][15] . In animal studies, histological examinations revealed enhanced fibroblastic and endothelial cell formation during wound healing, increased neovascularization [12,[19][20][21][22] , and enhanced granulation tissue formation [12,19,21,22] .…”

Section: Discussionmentioning

confidence: 99%

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Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

Özgürsoy

Tunçkaşık²,

Tunçkaşık³

et al. 2017

Int Adv Otol

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OBJECTIVE:To assess the efficacy of the application of platelet-rich plasma (PRP) in the healing process of acute tympanic membrane perforations (TMPs). MATERIALS and METHODS:Acute TMPs were made in both the ears of 12 New Zealand rabbits. Plasma gel was applied at the right tympanic membrane (TM) of the same animal until the perforations were closed. The left TM was left untreated. On days 1, 4, 7, 10, 13, 16, 21, 28, and 35, the TMs were monitored to check the closure of perforations. The days of perforation closure for the 2 groups were compared using the paired t-test. The animals were sacrificed 2 months after making the perforations. Seven histopathological parameters were reviewed by 2 blinded pathologists: acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, sclerosis, fibroblastic reaction, and an increase in the thickness of the squamous epithelial layer. The presence or absence of each histological parameter in both groups was compared using the Pearson Chi-square test. RESULTS:The average number of days for closure in the plasma gel group was 12 (range 8-18 days) and that in the control group was 17.7 (range 8-31 days). The difference was statistically significant (p=0.0145). There was no sclerosis or fibroblastic reaction in any of the specimens. No statistically significant difference was seen between the 2 groups with respect to acute inflammation, chronic inflammation, edema in the lamina propria, congestion in the lamina propria, and an increase in thickness of the squamous epithelial layer (p>0.05). CONCLUSION:Platelet-rich plasma fastens TMP closure; in long term, the eventual outcome is both microscopically and macroscopically same for the control as well as study groups in a rabbit traumatic TMP model. We believe that this study will encourage the clinical use of PRP for acute TMPs and trigger clinical studies in this field.

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The use of platelet-rich plasma in plastic surgery: A systematic review

Cited by 189 publications

References 43 publications

Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus)

Utilização de plasma rico em plaquetas para estimulação da angiogênese em flape de padrão axial toracodorsal em coelhos (Oryctolagus cuniculus)

Application of Platelet-Rich Plasma and Platelet-Rich Fibrin in Fat Grafting: Basic Science and Literature Review

Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations

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