The use of platelet‐rich plasma to enhance the outcomes of implant therapy: A systematic review

Abstract

ObjectiveTo assess the effect of platelet‐rich plasma (PRP) on implant dentistry. The primary focused question was as follows: What are the clinical, histological, and radiographic outcomes of PRP administration for bone regeneration and implant therapy?MethodsA literature search was conducted involving three databases: MEDLINE, EMBASE and Cochrane database followed by a hand search of relevant scientific journals. Human studies using PRP for bone regeneration and implant therapy were considered and articles published up to December 31, 2017 were included. Eligible studies were selected based on the inclusion criteria, and quality assessments were conducted.ResultsIn total, out from the 9,497 titles meeting the original search criteria, 22 fulfilled the inclusion criteria and were chosen for data extraction. Among them were 15 randomized controlled trials (RCT) and seven controlled clinical trials (CCT). Overall, the risk of bias was moderate to high. A total of seven studies showed superior outcomes when PRP was added during sinus floor elevation and five showed no superior outcome. Three studies found a significant advantage of PRP for alveolar bone regeneration and another three studies for soft tissue healing. Three studies reported on beneficial effects of PRP directly during implant placement while another study failed to find significant differences. Due to the heterogeneity of study designs, no meta‐analysis could be performed.Summary and ConclusionsDespite the lack of consistent evidence supporting the clinical benefit of PRP in healthy patients, PRP might have a positive effect on wound healing and bone regeneration in compromised patients.

The Number of Platelets in Patient’s Blood Influences the Mechanical and Morphological Properties of PRP-Clot and Lysophosphatidic Acid Quantity in PRP

“…The use of platelet concentrates in combination with natural and synthetic biomaterials has been widely assessed and examined, with the aim of obtaining a faster and better bone healing [1]. Platelet-rich plasma (PRP) is a widely used biomaterial for bone tissue regeneration, both as a three-dimensional scaffold with filling function and as a pharmacologically active compound capable of stimulating cell migration and cell proliferation at the site of the lesion [2][3][4]. Other strategies in bone remodeling/repairing exist.…”

Drugs and diseases: Summary and consensus statements of group 1. The 5thEAO Consensus Conference 2018

“… Stähli A, Strauss FJ, Gruber R. () The use of platelet‐rich‐plasma to enhance the outcomes of implant‐related therapies: a systematic review Strauss FJ, Stähli A, Gruber R. (2018) The use of platelet‐rich‐fibrin to enhance the outcomes of implant‐related therapies: a systematic review Mombelli A, Hashim D, Cionca N. () What is the impact of titanium particles and bio‐corrosion on implant survival and complications? A critical review Stavropoulos A, Bertl K, Pietschmann P, Pandis N, Morten Schiødt, Klinge B.…”

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

“…It is also possible to create mixtures of materials using either autologous bone or growth or hormonal factors, such as PRF or CGF (Platelet Rich Fibrin or Concentrated Growth Factor). This improves tissue response by mixing the capabilities and characteristics of one biomaterial with another [59][60][61]. The possible contamination of the materials or even the post-surgical resorption of the latter can make implant-prosthetic rehabilitation less predictable, exposing the implant fixtures to a risk of peri-implant disease [62], leading to acute and then chronic inflammatory processes that could lead to failure if not treated [63].…”