The use of platelet-rich plasma on the experimental corneal erosion

Тарабрина, В. А.; Gavrilyuk, I.O.; Churashov, Sergey V.; Куликов, А.Н.

doi:10.25276/2312-4911-2020-3-83-84

Cited by 2 publications

(1 citation statement)

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“…Терапия такой плазмой является безопасным методом лечения и показания к её применению неуклонно расширяются [4]. Так, данные технологии могут быть использованы в хирургии макулярного разрыва, хирургии регматогенной отслойки сетчатки, при патологии роговицы [5][6][7][8].…”

Section: оригинальные статьиunclassified

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Popov

Куликов

Churashov

et al. 2021

Ophthalmology Reports

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BACKGROUND: In recent years, autologous serum has been increasingly used in the treatment of macular hole. The study carried out a biological analysis of autologous serum obtained by various methods. AIM: The aim of the investigation is to compare the cellular and biochemical composition of autologous serum obtained using different methods for use in the macular hole treatment. MATERIALS AND METHODS: The study of the number of platelets, leukocytes and fibrinogen level in the blood serum of 24 patients obtained by centrifugation in original systems for harvesting autologous serum and laboratory test tubes was performed. RESULTS: The indices of P-PRP obtained in the Arthrex ACP system and in a laboratory test tube do not statistically differ in quantitative indices of fibrinogen and platelets (p 0.05), and differ in the content of leukocytes (p 0.05) in the direction of increasing the number of leukocytes in the substrate obtained in a laboratory test tube. The indicators of L-PRP obtained in the Ycellbio-Kit system and in a laboratory test tube do not statistically differ in the amount of fibrinogen (p 0.05) and differ in the content of platelets and leukocytes (p 0.05) in the direction of decreasing the concentration of leukocytes and platelets in the autologous serum obtained in a laboratory test tube. CONCLUSIONS: Currently, autologous serum obtained in the Arthrex ACP system is of great interest for macular hole surgery due to the minimal content of leukocytes, the closed character of the system, and the best coagulation properties of the substrate obtained. Laboratory test tubes may be considered a more affordable alternative for the production of autologous serum (P-PRP) for the treatment of macular hole. The autologous serum (L-PRP) obtained in the Ycellbio-Kit system and in a laboratory test tube is less suitable for macular hole surgery according to its composition.

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Section: оригинальные статьиunclassified

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Popov

Куликов

Churashov

et al. 2021

Ophthalmology Reports

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Mechanisms of closure of central and peripheral retinal tears using PRP plasma

Shamkin,

Subbotina,

Stepanyants

2023

jour

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Introduction Research into the use of platelet-enriched plasma has been conducted in various fields of medicine over the last decade. In ophthalmology, autologous blood plasma products are widely used for retinal pathologies such as macular rupture, retinal detachment, and inflammatory and degenerative corneal diseases.The aim of the work was to prove on the basis of current data on the pathogenetic mechanisms of platelet-enriched plasma its effectiveness and safety in retinal surgery and to substantiate the possibility of its use in eye injuries.Materials and methods A search of scientific literature and publications in PubMed, CyberLeninka, eLibrary databases and electronic libraries was performed using the search words and phrases: platelet-rich plasma, platelet growth factors, macular rupture, retinal detachment, vitrectomy.Results and discussion The mechanisms of action of PRP plasma in retinal surgery are due to the high concentration of platelets. By participating in hemostasis, these blood cells trigger a cascade of reactions leading to the formation of a fibrin mesh, which, by contracting, pulls the edges of retinal tears together. In addition, the rich composition of platelet alpha granules after degranulation provides the tissue with a pool of growth factors that stimulate and accelerate tissue regeneration. The most studied of these are: PDGF, VEGF, TGF, IGF1, PF4, EGF, bFGF.Conclusion Platelet-enriched plasma preparations and their individual components are promising in the treatment of retinal diseases and are safe because they are autologous. Studies prove their efficacy in the treatment of retinal tears, which can be used to close defects of traumatic etiology.

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The use of platelet-rich plasma on the experimental corneal erosion

Cited by 2 publications

References 0 publications

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Comparison of indicators of autologous serum obtained by different methods and used for the treatment of macular hole

Mechanisms of closure of central and peripheral retinal tears using PRP plasma

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