The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Thu, Aung Chan

doi:10.12701/jyms.2022.00290

Cited by 16 publications

(7 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method has gained popularity in the treatment of various muscle injuries due to its autologous nature, minimal invasiveness, lack of side effects, and greater availability and affordability compared to o ther methods. The mechanism of action of PRP in the treatment of various injuries is a complex multi-step process involving the rege ne ration factors and more effective muscle repair [3,24].…”

Section: Resultsmentioning

confidence: 99%

Potentials and impact of platelet-rich plasma (PRP) on the regenerative properties of muscle tissue

Dzhyvak,

Klishch,

Khlibovska

et al. 2024

Biopolym. Cell

View full text Add to dashboard Cite

Background. Platelet-Rich Plasma (PRP) is often used in various fields of medicine. The current state of the art in the use of PRP holds great promise for the development of the methodology. PRP can improve the course of many diseases. In this article the impact of PRP on the regenerative properties of muscles is discussed. There are many protocols for preparing PRP, each with its own standardised parameters and claimed results. The article presents a review of the literature on the use of platelet-rich plasma, focusing on the definition of PRP, various methods of preparation and activation, as well as the concentration of growth factors. K e y w o r d s:platelet-rich plasma, muscle regeneration, recovery, muscle injuries, tissue repair.

show abstract

Section: Resultsmentioning

confidence: 99%

Potentials and impact of platelet-rich plasma (PRP) on the regenerative properties of muscle tissue

Dzhyvak,

Klishch,

Khlibovska

et al. 2024

Biopolym. Cell

View full text Add to dashboard Cite

show abstract

“…PRP injection side effects included post-injection soreness and stiffness, chest pain, dyspnea, jitteriness, and pain on the opposite side [ 34 ]. Results may vary depending on PRP preparation techniques, activator kinds, pathology types to be treated, administration routes and timings, and PRP's interaction with other therapies [ 35 ]. Second, there is a lack of standardization and heterogeneity in PRP preparations.…”

Section: Reviewmentioning

confidence: 99%

Injections of Platelet-Rich Plasma: An Emerging Novel Biological Cure for Low Back Pain?

Jayasoorya,

Samal,

Pisulkar

et al. 2024

Cureus

View full text Add to dashboard Cite

Autologous platelet-rich plasma (PRP) injections have emerged as a new biological intervention for many musculoskeletal conditions, such as low back pain (LBP), and have garnered significant attention in recent research endeavors. The recognition of PRP's use is progressively growing; nonetheless, comprehensive clinical validation is required to establish its uses and efficiency. This article offers a thorough evaluation regarding the assurance as well as the efficacy of PRP therapy in the management of low back pain. It specifically focuses on the analysis of clinical trials undertaken in this field.

show abstract

“…The most studied orthobiologic agent is platelet-rich plasma (PRP), which is easily obtained through peripheral blood centrifugation [ 12 ]. The efficacy and safety of PRP use in orthopedic patients, especially those with knee arthrosis, are well supported in the literature, allowing for pain control and improvement in clinical scores [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.

show abstract

The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review

Cited by 16 publications

References 96 publications

Potentials and impact of platelet-rich plasma (PRP) on the regenerative properties of muscle tissue

Potentials and impact of platelet-rich plasma (PRP) on the regenerative properties of muscle tissue

Injections of Platelet-Rich Plasma: An Emerging Novel Biological Cure for Low Back Pain?

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Contact Info

Product

Resources

About