The use of poly(dimethylsiloxane) surface modification with gold nanoparticles for the microchip electrophoresis

Wang, Ai‐Jun; Xu, Jing‐Juan; Zhang, Qing; Chen, Hong‐Yuan

doi:10.1016/j.talanta.2005.09.029

Cited by 72 publications

(53 citation statements)

References 35 publications

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“…Liu et al 29 coated PDMS microchips with a bilayer of polybrene and dextran sulfate, and they obtained a stable EOF. Chen's group 30,31 had reported gold nanoparticle and protein-coated PDMS microchannels and successfully used them to separate dopamine and epinephrine.…”

Section: Introductionmentioning

confidence: 99%

Separation and Simultaneous Determination of Uric Acid and Ascorbic Acid on a Dynamically Modified Poly(dimethylsiloxane) Microchip

Qiu

Liang

2007

ANAL. SCI.

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Poly(dimethylsiloxane) microfluidic channels alternately modified by poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate) were successfully used to separate uric acid and ascorbic acid. Results show that uric acid and ascorbic acid can be well separated and detected simultaneously in modified microchips coupled with in-channel electrochemical detection. Under the optimal conditions, the linear ranges of uric acid and ascorbic acid were both from 25 to 600 μM, with the correlation coefficients of 0.997 and 0.996, respectively. The detection limits were 8 μM for uric acid and 5 μM for ascorbic acid. Factors influencing separation and detection, including buffer solution, detection potential and separation voltage, were investigated and optimized. In addition, the dependences of the current response on sensitivity and reproducibility were studied, and the stability of the device was also evaluated in detail. This method was successfully used to determine uric acid and ascorbic acid in human urine.

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Section: Introductionmentioning

confidence: 99%

Separation and Simultaneous Determination of Uric Acid and Ascorbic Acid on a Dynamically Modified Poly(dimethylsiloxane) Microchip

Qiu

Liang

2007

ANAL. SCI.

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“…The previous work exhibited that the response current of the GCE/AuNPs and GCE/MWCNTs sensors [17,[19][20][21] were linear in the range from 10 -6 to 10 -4 mol.L -1…”

Section: Electrode Response Characteristics and Calibration Of Da Sensormentioning

confidence: 99%

“…Many modified electrodes based on CNTs have been widely used for the study of DA, such as CNTs paste modified electrode, single walled carbon nanotube-modified platinum electrode [14], single-walled carbon nanotubes-Fc modified glassy carbon electrode (GCE) [15], Nafion/carbon nanotubes coated poly(3-methylthiophene) modified GCE [16], multi-walled carbon nanotubes (MWCNTs) modified gold electrode [17], layer-by-layer assembled MWCNTs modified electrode [18], etc. In many cases, the sensors based on CNTs or AuNPs the have the detection limit of about 1 µmol.L -1 or lower [17,[19][20][21]. Hence, improving the selectivity and sensitivity of the DA sensor is still a significative research.…”

Section: Introductionmentioning

confidence: 99%

Selective response of dopamine in the presence of ascorbic acid and uric acid at gold nanoparticles and multi-walled carbon nanotubes grafted with ethylene diamine tetraacetic acid modified electrode

Tang¹,

Wang²,

Su³

et al. 2009

Bull. Chem. Soc. Eth.

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ABSTRACT.ABSTRACT. ABSTRACT. ABSTRACT. By grafting with ethylene diamine tetraacetic acid (EDTA), novel multi-walled carbon nanotube nano-composites (EDTA-MWCNTs) have been successfully prepared. The integration of gold nanoparticles (AuNPs) and novel functionalized matrix shows very promising applications in the fabrication of biosensors for sensitive detection of dopamine in the presence of ascorbic acid and uric acid with the combination of the charge repelling property of carboxylic anion and the electrocatalytic effect of EDTA. The AuNPs and EDTA-MWCNTs modified film shows excellent sensitivity and selectivity for the dopamine analysis due to the synergic effect of AuNPs and EDTA-MWCNTs. As high as 2000 fold and 150 fold acceptable tolerance of ascorbic acid and uric acid for the determination of trace dopamine is reached, respectively. The linear concentration range for dopamine is from 1.0 × 10 -8 to 6.0 × 10 -6 mol.L -1, and the detection limit is 3.0 × 10 -9 mol.L -1 . The response of the sensor is very quick and response time is less than 1 s. The method can be applied to detect the dopamine in human urine samples. KEY WORDS: KEY WORDS: KEY WORDS:

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“…14 The polyelectrolyte modification of microreactor surfaces is a versatile method in terms of layer optimization which allows fine tailoring of interfacial properties of glass, silicon, and poly(dimethylsiloxane) (PDMS). [15][16][17] During the last two decades, research has been performed on polyelectrolyte stability, 18 growth regimes, 19,20 and interaction with proteins. 21,22 Additionally, specific knowledge on PEI charge density, 23,24 adsorption behavior, 25,26 and dynamics of protein interactions at interfaces 27 provide us solid ground for further exploration and implementation of the PEI=DSS couple in a biomicroreactor.…”

Section: Introductionmentioning

confidence: 99%

Pheromone synthesis in a biomicroreactor coated with anti-adsorption polyelectrolyte multilayer

Dimov

Muñoz²,

Carot-Sans³

et al. 2011

Biomicrofluidics

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To prepare a biosynthetic module in an infochemical communication project, we designed a silicon=glass microreactor with anti-adsorption polyelectrolyte multilayer coating and immobilized alcohol acetyl transferase (atf), one of the key biosynthetic enzymes of the pheromone of Spodoptera littoralis, on agarose beads inside. The system reproduces the last step of the biosynthesis in which the precursor diene alcohol (Z,E)-9,11-tetradecadienol is transformed into the major component (Z,E)-9,11-tetradecadienyl acetate. The scope of this study was to analyze and implement a multilayer, anti-adsorption coating based on layer-bylayer deposition of polyethylenimine=dextransulfate sodium salt (PEI=DSS). The multilayers were composed of two PEI with molecular weights 750 and 1.2 kDa at pH 9.2 or 6.0. Growth, morphology, and stability of the layers were analyzed by ellipsometry and atomic force microscopy (AFM). The anti-adsorption functionality of the multilayer inside the microreactor was validated. The activity of His 6 -(atf) was measured by gas chromatography coupled to mass spectrometer (GC-MS).

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The use of poly(dimethylsiloxane) surface modification with gold nanoparticles for the microchip electrophoresis

Cited by 72 publications

References 35 publications

Separation and Simultaneous Determination of Uric Acid and Ascorbic Acid on a Dynamically Modified Poly(dimethylsiloxane) Microchip

Separation and Simultaneous Determination of Uric Acid and Ascorbic Acid on a Dynamically Modified Poly(dimethylsiloxane) Microchip

Selective response of dopamine in the presence of ascorbic acid and uric acid at gold nanoparticles and multi-walled carbon nanotubes grafted with ethylene diamine tetraacetic acid modified electrode

Pheromone synthesis in a biomicroreactor coated with anti-adsorption polyelectrolyte multilayer

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