The use of poly (ε‐caprolactone) to enhance the mechanical strength of porous Si‐substituted carbonate apatite

Bang, L. T.; Kawachi, Giichiro; Nakagawa, Masaharu; Munar, Melvin L.; Ishikawa, Kunio; Othman, Radzali

doi:10.1002/app.39164

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Along this line, PCL is used as a slowly biodegradable but well biocompatible polymer. PCL/HA and PCL/CDHA biocomposites have been already discussed as suitable materials for substitution, regeneration and repair of bone tissues [ 262 , 345 , 346 , 347 , 348 , 349 , 350 , 351 , 352 ]. For example, biocomposites were obtained by infiltration of ε-caprolactone monomer into porous apatite blocks and in situ polymerization [ 346 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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“…1 PCL is also very frequently employed in the fabrication of biomedical devices and in the preparation of pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, it has been used also in composites of silicon-substituted carbonate apatite, which thanks to the PCL presence show increased mechanical resistance and can therefore be used as structural material. 1 PCL is also very frequently employed in the fabrication of biomedical devices and in the preparation of pharmaceutical products. The main motivation for using PCL in these latter applications lies in its biocompatibility.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Poly-ε-caprolactone (PCL) is a saturated aliphatic polyester with hexanoate repeated units and, because of a number of interesting properties, is currently employed and studied in a broad range of applications. Recently, it has been used also in composites of silicon-substituted carbonate apatite, which thanks to the PCL presence show increased mechanical resistance and can therefore be used as structural material . PCL is also very frequently employed in the fabrication of biomedical devices and in the preparation of pharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

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Solvent Structuring and Its Effect on the Polymer Structure and Processability: The Case of Water–Acetone Poly-ε-caprolactone Mixtures

2014

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One of the most common processes to produce polymer nanoparticles is the solvent-displacement method, in which the polymer is dissolved in a "good" solvent and the solution is then mixed with an "anti-solvent". The polymer processability is therefore determined by its structural and transport properties in solutions of the pure solvents and at the intermediate compositions. In this work, we focus on poly-ε-caprolactone (PCL) which is a biocompatible polymer that finds widespread application in the pharmaceutical and biomedical fields, performing full atomistic molecular dynamics simulations of one PCL chain of different molecular weight in a solution of pure acetone (good solvent), of pure water (antisolvent), and their mixtures. Our simulations reveal that the nanostructuring of one of the solvents in the mixture leads to an unexpected identical polymer structure irrespectively of the concentration of the two solvents. In particular, although in pure solvents the behavior of the polymer is, as expected, very different, at intermediate compositions, the PCL chain shows properties very similar to those found in pure acetone as a result of the clustering of the acetone molecules in the vicinity of the polymer chain. We derive an analytical expression to predict the polymer structural properties in solution at different solvent compositions and show that the solvent clustering affects in an unpredictable way the polymer diffusion coefficient. These findings have important consequences on the optimization of the nanoparticle production process and in the implementation of continuum modeling techniques to model it.

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“…A number of researchers have reported the use of polymer infiltration into bioceramic scaffolds to increase mechanical properties [35][36][37][38][39][40] . In these studies, bioceramic porous structures were immersed in molten polymer or solution to achieve infiltration of either the filaments or the entire structure.…”

Section: Discussionmentioning

confidence: 99%

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2024

IJB

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Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone with favourable biocompatibility. However, natural grade PEEK-OPTIMA has shown insufficient bioactivity and limited bone integration. Bioactive PEEK composites (e.g., PEEK/calcium phosphates or Bioglass) and porous PEEK have been used to improve bone-implant interface of PEEK-based devices, but the bioactive phase distribution or porosity control is poor. In this paper, a novel method is developed to fabricate a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the HA (bioactive phase) distribution is computer-controlled within a PEEK matrix. This novel process results in complete interconnectivity of the HA network within a composite material, representing a superior advantage over alternative forms of product. The technique combines extrusion freeforming, a type of additive manufacturing (AM), and compression moulding. Compression moulding parameters, including pressure, temperature, dwelling time, and loading method together with HA microstructure were optimized by experimentation for successful biocomposite production. PEEK/HA composites with a range of HA were produced using static pressure loading to minimise air entrapment within PEEK matrix. In addition, the technique can also be employed to produce porous PEEK structures with controlled pore size and distribution.

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The use of poly (ε‐caprolactone) to enhance the mechanical strength of porous Si‐substituted carbonate apatite

Cited by 7 publications

References 38 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Solvent Structuring and Its Effect on the Polymer Structure and Processability: The Case of Water–Acetone Poly-ε-caprolactone Mixtures

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

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