Interferometric synthetic aperture radar is an effective means of measuring changes in the altitude of the Earth’s surface. In this research, the areas of surface deformation associated with low- and medium-intensity seismic events in Central Chile were analyzed using SENTINEL 1 satellite radar interferograms and geographical information system (GIS) tools. The persistent scatterer method was used to reduce noise from conventional InSAR methods. The results revealed that the coastal zone of Central Chile has a high density of daily earthquakes with a prevalence (93.03%) of low- and medium-intensity earthquakes. Monthly deformation maps were developed for the coast of the Biobio region in Central Chile. A clear deformation pattern is defined along the coast, being greater in the Arauco, Lota and Lebu areas. It was also shown that there was a slight upward trend in the north and northeast zone (i.e., δup ~3 mm/year), while there was an obvious accentuated upward trend (i.e., δup ~24 mm/year) in the southern part. This movement increases as latitude increases. This pattern is related to the daily seismic activity, the product of the movement between plates, and the geological faults located in the area. The deformation and trend maps provide certainty in terms of where hotspots are located, e.g., the most hazardous areas in the study zone, which can be applied to urban planning and/or safety assessment.