The use of porphyrins in potentiometric sensors as ionophores

Özbek, Oğuz; Işıldak, Ömer; Berkel, Çağlar

doi:10.1007/s10847-020-01004-y

Cited by 39 publications

(15 citation statements)

References 42 publications

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“…Porphyrins are widely used in areas such as photochemistry, photophysics, photovoltaics, biological system, and optics due to their specific structure and their various advantages over alternatives. [ 3 ] In addition, porphyrin derivatives can be used directly as an ionophore in the construction of different chemical sensors, especially in that potentiometry‐based ones. In this study, we developed a potentiometric sensor selective for Cu 2+ ions using a porphyrin derivative molecule as an ionophore.…”

Section: Discussionmentioning

confidence: 99%

“…[2] Porphyrin derivatives used as ionophores in the literature have been proven to be excellent sensor materials for different real sample analyses such as environmental monitoring, food, medical and pharmaceutical analysis. [3] Potentiometry-based sensors, which are one of the electroanalytical methods have attracted the increasing attention of researchers for a long time due to their features such as wide concentration range, low detection limit, short response time, low energy consumption, experimental simplicity, good selectivity, ease of miniaturization and low cost. [4][5][6][7] Potentiometry-based sensors have been applied in many areas such as in the determination of various inorganic and organic ions, environmental monitoring, medicinal drug analysis, industrial analysis, and routine laboratory analysis.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potentiometric determination of copper(II) ions based on a porphyrin derivative

Özbek

Işıldak

2022

J Chinese Chemical Soc

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A novel poly(vinyl chloride; PVC) membrane‐based Cu(II)–selective sensor has been developed using synthesized 5,10,15,20‐tetrakis(4‐methoxycarbonylphenyl)porphyrin as an ionophore. The Cu(II)–selective sensor exhibits a Nernstian response for Cu(II) ion over a wide concentration range of 1.0 × 10−5 to 1.0 × 10−1 mol L−1 with the slope of 27.0 ± 2.5 mV/decade, and a lower limit of detection of 1.88 × 10−6 mol L−1. The novel sensor shows good repeatability and high selectivity for Cu(II) ions over other mono‐, bi‐ and trivalent cations. The sensor potential response remains unaffected by pH in the range of 4.4–10.6 and exhibits a fast response time of less than 10s. Finally the developed Cu(II)–selective sensor has been successfully used as an indicator electrode in the potentiometric titration of Cu2+ against ethylenediaminetetraacetic acid and also in the determination of Cu(II) ion concentration in different water and beverage samples.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potentiometric determination of copper(II) ions based on a porphyrin derivative

Özbek

Işıldak

2022

J Chinese Chemical Soc

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“…There are several applications for potentiometric sensors for example quality control and quality assurances of drugs, agricultural analysis, metal ions detection, small molecules detection, detection of enzymes, DNA analysis, environmental assessment, industrial analysis, and pharmaceutical drug monitoring (Fig. 1) 5,6 . Potentiometric sensors as sensing tools have presented many advantages as it allows the determination of various analytes in a wide range of concentrations and employs inexpensive measurement equipment.…”

Section: Introductionmentioning

confidence: 99%

“…With the recent progress in ISEs, most of the potentiometric sensors that have been utilized for the determination of pharmaceutical drugs and in therapeutic drug monitoring were relied on using ISEs 12,13 . Notably, potentiometric sensors have been commonly applied for pharmaceutical drug analysis more than other analytical approaches due to their several merits such as excellent target selectivity and high sensitivity, fast analysis time, high stability, low LOD, resistant to color and turbid interferences, wide linear range, relatively low cost and ease of usage [14][15][16][17][18] . In the present review, we summarized the potentiometric platforms which were established for the detection of different pharmaceutical drugs in their different dosage forms as well as their biological fluids such as milk, plasma and urine, and discussed their numerous analytical performances such as linear concentration, LOD, response time, lifetime and their applications.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric sensors for the determination of pharmaceutical drugs

et al. 2022

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Potentiometric sensors based on ion-selective membrane electrodes have continued to get great attention from the scientific community. These sensors have been employed in several applications including medicine, forensic analysis, environmental assessment, industry, agriculture, and pharmaceutical drug analysis. Indeed these sensors possess several advantages for example simple design, fabrication, and manipulation, rapid response time, good selectivity, applicability to colored and turbid solutions, and possible interfacing with automated and computerized systems. On the other hand, therapeutic drug monitoring and detection of pharmaceutical drugs in their pharmaceutical formulations and biological matrices are highly significant from a medical point of view especially for drugs with a narrow therapeutic index such as anticancer drugs which can cause fatal side effects for patients. Interestingly, potentiometric sensors have been broadly employed as one of the most important electrochemical approaches for pharmaceutical drug analysis. Moreover, the breakthroughs in potentiometric sensors based on ion-selective electrodes (ISEs) make them superior to the other reported methods for pharmaceutical drug analysis in terms of many performance parameters such as sensitivity, selectivity, low detection limit, and low cost. In this review, we try to offer a summary prologue to the applicability and merits of the potentiometric sensors that have been employed for pharmaceutical drug analysis emphasizing their application for the assay of pharmaceutical drugs in their dosage forms and the in-vivo assay of pharmaceutical drugs in different biological samples such as milk, water, plasma, and urine.

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Versatile Metalloporphyrin‐Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules

2023

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At the beginning of his youthful sixth decade, this work is dedicated to Prof. Dr. Fabio Doctorovich. He is distinctive in organometallic chemistry. During his successful career, he has been studying the reactivity and application of metalloporphyrins. Metalloporphyrins are organometallic complexes that exhibit, through synthetic modifications, the ability to tune their optical and electrochemical properties and their selectivity towards a particular molecule or ion. For this reason, they are systems extremely useful as electrochemical sensors to detect and quantify a wide variety of analytes with high selectivity, even in real samples such as food, water, biological fluids, or pharmaceutical compounds. This review presents an up-to-date list of reports in which metalloporphyrins are used as electrochemical sensors. In addition to compiling a comprehensive and up-to-date list of reported sensors that utilize metalloporphyrins, this work aims to provide an overview of currently available tools and techniques for the detection of various chemical species through similar approaches, which are constantly being developed.

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The use of porphyrins in potentiometric sensors as ionophores

Cited by 39 publications

References 42 publications

Potentiometric determination of copper(II) ions based on a porphyrin derivative

Potentiometric determination of copper(II) ions based on a porphyrin derivative

Potentiometric sensors for the determination of pharmaceutical drugs

Versatile Metalloporphyrin‐Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules

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