SUMMARYRepeaters are now widely used to enhance the performance of long on-chip interconnects in CMOS devices. For RC-as well as RLC-modeled interconnects, parallel repeaters (PRs) have proved to be superior to serial ones. In a previous work, a new regeneration technique, named variable-segment, was proven to outperform other existing regeneration techniques including variable-repeater techniques. In this paper, an approximate analytical delay model is presented for both the variable-repeater and variable-segment parallel regeneration techniques. This model is used to confirm the optimality of our design and is built based on first and second-moment transfer functions, which take into account the inductive effects of interconnects. HSpice electrical and C++/MATLAB simulations are conducted to assess the performance of the proposed optimization methodology using 0.25-m CMOS technology. The mathematical simulation results are remarkably in agreement with those obtained from electrically simulated variable-repeater and variable-segment structures which are used in this work to regenerate interconnect lengths ranging from 0.1 to 10 cm. This work is part of a first-of-its-kind global theory on PRs in repeater-insertion methodologies for long on-chip interconnects. This theory aims at exploring the different degrees of freedom in interconnect modeling as well as repeater type and design parameters.