The use of propranolol for complicated infantile hemangiomas

Vercellino, Nadia; Romanini, Maria Victoria; Pelegrini, Monica; Alessandro, Riccardo; Occella, C.; Dalmonte, Pietro

doi:10.1111/j.1365-4632.2012.05795.x

Cited by 13 publications

(7 citation statements)

References 43 publications

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“…Vercellino et al. , who started the administration at 1 mg/kg per day and increased to 2 mg/kg per day, and Sadykov et al. , who started the administration at 2 mg/kg per day, also reported that propranolol was effective.…”

Section: Resultsmentioning

confidence: 99%

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Mimura

Akita

Fujino

et al. 2020

The Journal of Dermatology

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQ) were decided based on the important clinical issues. For document retrieval, key words for published work searches were set for each CQ, and work published from 1980 to the end of September 2014 was searched in PubMed, Cochrane Library and Japana Centra Revuo Medicina databases. The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System technique. A total of 33 CQ were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence-based guidelines for the management of vascular anomalies.

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Section: Resultsmentioning

confidence: 99%

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Mimura

Akita

Fujino

et al. 2020

The Journal of Dermatology

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“…Moreover, mTOR regulates the self-renewal and vasculogenic potential of HemSCs, and its specific inhibitor rapamycin exerts excellent curative effects in cellular and animal models (Greenberger et al, 2011). Meanwhile, the non-specific beta-blocker propranolol cures severe IHs (Leaute-Labreze et al, 2013;Vercellino et al, 2013). Propranolol possibly prevents IH progression by suppressing both Akt and Erk1/2 pathways (Zou et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Macrophages Contribute to the Progression of Infantile Hemangioma by Regulating the Proliferation and Differentiation of Hemangioma Stem Cells

Zhang

Chen

Wang

et al. 2015

Journal of Investigative Dermatology

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Macrophage infiltration has been implicated in infantile hemangioma (IH), the most common tumor of infancy. However, the exact role of macrophages in IH remains unknown. This study aims to clarify the functional significance of macrophages in the progression of IH. The distribution of macrophages in human IH was analyzed, and our results revealed that polarized macrophages were more prevalent in proliferating IHs than in involuting IHs, which was consistent with the increased macrophage-related cytokines in proliferating IHs. In vitro results further demonstrated that polarized macrophages effectively promoted the proliferation of hemangioma stem cells (HemSCs) and suppressed their adipogenesis in an Akt- and extracellular signal-regulated kinase 1/2 (Erk1/2)-dependent manner. Moreover, M2- but not M1-polarized macrophages promoted the endothelial differentiation of HemSCs. Furthermore, mixing macrophages in a murine hemangioma model elevated microvessel density and postponed fat tissue formation, which was concomitant with the activation of Akt and Erk1/2 signals. Cluster analysis revealed a close correlation among the macrophage markers, Ki67, vascular endothelial growth factor (VEGF), p-Akt, and p-Erk1/2 in human IH tissues. Collectively, our results suggest that macrophages in IH contribute to tumor progression by promoting the proliferation and endothelial differentiation while suppressing the adipogenesis of HemSCs. These findings indicate that targeting the infiltrating macrophages in IH is a promising therapeutic approach to accelerate IH regression.

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“…Vercellino et al, 202 who started the administration at 1 mg/ kg/day and increased to 2 mg/kg/day, and Sadykov et al, 203 who started the administration at 2 mg/kg/day, also reported that propranolol was effective.…”

Section: Oral Propranololmentioning

confidence: 99%

Japanese clinical practice guidelines for vascular anomalies 2017

Mimura

Akita

Fujino

et al. 2020

Pediatrics International

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of September 2014 was searched in Pubmed, Cochrane Library, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System (MINDS) technique. A total of 33 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence‐based guidelines for the management of vascular anomalies.

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The use of propranolol for complicated infantile hemangiomas

Abstract: Propranolol should be used as first-line medical treatment in all cases of complicated infantile hemangiomas.

Cited by 13 publications

References 43 publications

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Macrophages Contribute to the Progression of Infantile Hemangioma by Regulating the Proliferation and Differentiation of Hemangioma Stem Cells

Japanese clinical practice guidelines for vascular anomalies 2017

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