The Use of Prostigmine in the Heartburn of Pregnancy

Bower, David

doi:10.1111/j.1471-0528.1961.tb02824.x

Cited by 2 publications

(15 citation statements)

References 2 publications

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“…The search identified 16 reports, related to 15 studies. Six studies have been excluded (Atlay 1978;Briggs 1972;Carne 1964;Hey 1978;Marks 1997) and nine studies have been included in the review (Bower 1961;Brunclik 1988;da Silva 2009;Kovacs 1990;Lang 1989;Ranchet 1990;Rayburn 1999;Reisfield 1971;Shaw 1978).…”

Section: Results Of the Searchmentioning

confidence: 99%

Interventions for heartburn in pregnancy

Phupong

Hanprasertpong

2015

Cochrane Database of Systematic Reviews

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There are no large-scale RCTs to assess heartburn relief in pregnancy. This review of nine small studies (which involved data from only four small studies) indicates that there are limited data suggesting that heartburn in pregnancy could be completely relieved by pharmaceutical treatment. Three outcomes were assessed and assigned a quality rating using the GRADE methods. Evidence from two trials for the outcome of complete relief of heartburn was assessed as of moderate quality. Evidence for the outcomes of partial heartburn relief and side effects was graded to be of very low quality. Downgrading decisions were based in part on the small size of the trials and on heterogenous and imprecise results.There are insufficient data to assess acupuncture versus no treatment and no data to assess other comparisons (miscarriage, preterm labour, maternal satisfaction, fetal anomalies, intrauterine growth restriction, low birthweight).Further RCTs are needed to fully evaluate the effectiveness of interventions for heartburn in pregnancy. Future research should also address other medications such as histamine 2-receptor antagonists, promotility drugs, proton pump inhibitors, and a raft-forming alginate reflux suppressant in treatment of heartburn in pregnancy. More research is needed on acupuncture and other complimentary therapies as treatments for heartburn in pregnancy. Future research should also evaluate any adverse outcomes, maternal satisfaction with treatment and measure pregnant women's quality of life in relation to the intervention.

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Section: Results Of the Searchmentioning

confidence: 99%

Interventions for heartburn in pregnancy

Phupong

Hanprasertpong

2015

Cochrane Database of Systematic Reviews

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“…Fifteen studies were identified by the search strategy. Of these, only three were eligible for inclusion (Bower 1961; Rayburn 1999; Reisfield 1971), and one study is awaiting assessment (Marks 1997). Studies were excluded for a number of reasons.…”

Section: Resultsmentioning

confidence: 99%

“…The sample sizes in the three studies were small, ranging from 30 to 156. One of the studies was carried out almost 50 years ago (Bower 1961) and examined a treatment rarely used nowadays.…”

Section: Resultsmentioning

confidence: 99%

“…All three studies found a positive effect associated with interventions. In a study comparing women receiving intramuscular (IM) prostigmine versus an IM placebo more women had symptoms alleviated by the intervention (risk ratio (RR) 0.40, 95% confidence interval (CI) 0.23 to 0.69) (Bower 1961). Results from a trial examining the effect of a calcium based antacid plus ranitidine versus antacid alone also produced positive results in favour of the intervention group, although results did not reach statistical significance.…”

Section: Resultsmentioning

confidence: 99%

“…The three included studies focused on different interventions, so it was not possible to pool the results from trials. One of the studies focused on the use of IM prostigmine, and we are not aware that this intervention is currently used in the treatment of pregnancy heartburn (Bower 1961). In view of the very limited information available, it is not possible to draw conclusions on the overall effectiveness of interventions to treat heartburn in pregnancy.…”

Section: Resultsmentioning

confidence: 99%

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Interventions for heartburn in pregnancy

Dowswell

Neilson²

2008

Cochrane Database of Systematic Reviews

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Background-Heartburn is a common symptom in pregnancy affecting up to 80% of women in the third trimester. The reasons for the increase in symptoms in pregnancy are not well understood, but the effects of pregnancy hormones on the lower oesophageal sphincter and gastric clearance are thought to play a part. A range of interventions have been used to relieve symptoms including advice on diet and lifestyle, antacids, antihistamines, and proton pump inhibitors. The safety and effectiveness of these interventions to relieve heartburn in pregnancy have not been established.

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The Use of Prostigmine in the Heartburn of Pregnancy

Cited by 2 publications

References 2 publications

Interventions for heartburn in pregnancy

Interventions for heartburn in pregnancy

Interventions for heartburn in pregnancy

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