The use of rapid diagnostic test of Procalcitonin serum levels for the postmortem diagnosis of sepsis

Ramsthaler, Frank; Kettner, Mattias; Mall, Gerhard; Bratzke, H.

doi:10.1016/j.forsciint.2008.03.010

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…Postmortem diagnosis of sepsis is even more difficult to achieve, mainly because of the lack of medical records at the moment of the autopsy as well as the absence of specific macroscopic and microscopic findings (myocardial ischemia, pulmonary edema, hypoxic liver damage, mesenteric ischemia, gastrointestinal haemorrhages, spleen infarction, kidney ischemia and brain edema), which may be of infectious or noninfectious origin [3,9,10]. Thus, the postmortem usefulness of procalcitonin and CRP has been studied to discriminate between sepsis-related fatalities and systemic inflammatory response syndrome [9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the postmortem usefulness of procalcitonin and CRP has been studied to discriminate between sepsis-related fatalities and systemic inflammatory response syndrome [9][10][11][12][13][14][15][16][17]. Procalcitonin concentrations have been principally measured in the postmortem serum obtained from femoral blood, vitreous humor and cerebrospinal fluid [9][10][11]17]. CRP levels have been tested in the postmortem serum from femoral blood [12][13][14][15][16], liver [14], vitreous humor and cerebrospinal fluid [17].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, postmortem investigations have demonstrated that CRP levels can be used in forensic diagnosis in a similar manner to their use in clinical practice [10,[12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

et al. 2012

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The aim of this study was to investigate the presence and concentrations of procalcitonin and C-reactive protein in pericardial fluid and compare these levels to those found in the postmortem serum obtained from the femoral blood. Two groups were formed, a sepsis-related fatalities group and a control group. Postmortem native CT scans, autopsies, histology, neuropathology and toxicology as well as other postmortem biochemistry investigations were performed in all cases. Pericardial fluid procalcitonin levels were significantly different between the cases of sepsis-related fatalities and those of the control group. Postmortem serum procalcitonin levels below the detection limit were also reflected in undetectable pericardial fluid levels. Similarly, a large increase in postmortem serum procalcitonin levels was reflected in a large increase of procalcitonin pericardial fluid levels. Based on these findings, pericardial fluid could be an alternative to postmortem serum for the determination of procalcitonin levels in cases where postmortem serum is not available and measurements of procalcitonin are required to circumstantiate the pathogenesis of death

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

et al. 2012

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“…The study Tsokos et al [2] showed that the rate of Using post-mortem of the PCT has been validated against a diagnosis ante-mortem known [2] or in the autopsy or forensic scientists [6]. This study found a positive predictive value (PPV) and a specificity of 100% for a threshold value of 10 ng/mL for PCT.…”

Section: Discussionmentioning

confidence: 85%

Procalcitonin interest to assess a septic state inducing the death

Sadeg¹,

Tarlier²,

Veneau³

et al. 2013

FMAR

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In this prospective study, we evaluated the use of PCT when collecting the body which was carried out. The chosen cut-off was set at 10 ng/mL because at this level, the PCT was associated to a multiorgan failure attributable to a septic shock. For 90 cases, two groups were stratified by their final diagnosis: 33 of for non violent deaths and 57 of violent deaths. There was no significant elevation of procalcitonin rate (PCT) in the group of violent deaths. We noted 6 elevations of PCT rate above 10 ng/mL for non violent deaths (15.4%) and in 3 cases there was an evidence for an infectious context (recent antiinfectious treatments, chemotherapy in progress). Control of CRP performed on blood samples found initial elevations above 10 mg/L in 3 of the 6 cases (including 2 of 3 cases associated with an infectious context). There is no evidence of PCT rate increase for intermediate PMI (post mortem interval), long PMI and undefined PMI. This study found a PPV (positive predictive value) and clinical specificity of 100% for a cutoff set at 10 ng/mL. By taking this threshold, no significant PCT increase was observed in presence of death cases related to a violent origin as well as a fatal multi-organ failure due to malignant hyperthermia syndrome induced by neuroleptic use. The PCT appears to remain stable over time and whatever the conservation conditions of the body.

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“…In a study performed by Ramsthaler et al [76], postmortem serum PCT levels were determined in 70 forensic and 78 clinical-pathological autopsy cases, in order to evaluate whether a semi-quantitative test (rapid diagnostic test) was a reliable indicator of PCT levels. Postmortem serum was obtained from femoral vein blood.…”

Section: Procalcitoninmentioning

confidence: 99%

Postmortem chemistry update part II

Palmière

Mangin

2011

Int J Legal Med

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As a continuation of "Postmortem Chemistry Update Part I," Part II deals with molecules linked to liver and cardiac functions, alcohol intake and alcohol misuse, myocardial ischemia, inflammation, sepsis, anaphylaxis, and hormonal disturbances. A very important array of new material concerning these situations had appeared in the forensic literature over the last two decades. Some molecules, such as procalcitonin and C-reactive protein, are currently researched in cases of suspected sepsis and inflammation, whereas many other analytes are not integrated into routine casework. As in part I, a literature review concerning a large panel of molecules of forensic interest is presented, as well as the results of our own observations, where possible.

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The use of rapid diagnostic test of Procalcitonin serum levels for the postmortem diagnosis of sepsis

Cited by 21 publications

References 35 publications

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

Procalcitonin and C-reactive protein in pericardial fluid for postmortem diagnosis of sepsis

Procalcitonin interest to assess a septic state inducing the death

Postmortem chemistry update part II

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