The Use of Rheum Palmatum L. In the Treatment of Acute Respiratory Distress Syndrome: A Meta-Analysis of Randomized, Controlled Trials

Yang, Tie-zhu; Liu, Yan; Liu, Yueyun; Ding, Xin; Chen, Jiaxu; Kou, Mei-Jing; Zou, Xiaojuan

doi:10.21010/ajtcam.v14i2.35

Cited by 6 publications

(3 citation statements)

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“…It has been used for a variety of conditions, such as constipation, chronic renal failure, and upper gastrointestinal bleeding. It has antimicrobial and antioxidative effects [17,18] e toxicity includes hepatotoxicity and nephrotoxicity. No adverse reactions were observed in mice with a dose of 400 mg/kg [19] Carthamus tinctorius L., safflower, Hong Hua, 3-10 g e flowers of safflower contain kaempferol and hydroxysafflor yellow [20] It reduces immune inflammatory response [14].…”

Section: Size Of Neoplasmmentioning

confidence: 99%

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Xue

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. Methods. Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. Results. After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. Conclusion. External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744.

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Section: Size Of Neoplasmmentioning

confidence: 99%

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Xue

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Traditional Chinese medicine Rheum palmatum L. (Rhubarb) has been widely used for treating inflammatory diseases for thousands of years in China. Previous research reported that Rheum palmatum L. combined with routine comprehensive treatment remarkedly decreased the mortality of patients with acute respiratory distress syndrome by reducing the mechanical ventilation time, ameliorating the arterial blood gas and the cytokine levels ( Yang et al, 2017 ). Emodin, a main effective ingredient of Rhizoma palmatum L., has been reported to protect against ALI animal models, which is associated with the downregulation of the pre-B-cell colony-enhancing factor, upregulation of aquaporin 1 and aquaporin 2, and inhibition of NF-κB ( Xiao et al, 2014 ; Xu et al, 2016 ; Cui et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway

et al. 2022

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Background: Acute lung injury (ALI) is a serious inflammatory disease with clinical manifestations of hypoxemia and respiratory failure. Presently, there is no effective treatment of ALI. Although emodin from Rheum palmatum L. exerts anti-ALI properties, the underlying mechanisms have not been fully explored.Purpose: This study aimed to investigate the therapeutic effect and mechanism of emodin on LPS-induced ALI in mice.Methods: RAW264.7 cells and zebrafish larvae were stimulated by LPS to establish inflammatory models. The anti-inflammatory effect of emodin was assessed by ELISA, flow cytometric analysis, and survival analysis. In vitro mechanisms were explored by using Western blotting, luciferase assay, electrophoretic mobility shift assay (EMSA), and small interfering RNA (siRNA) approach. The acute lung injury model in mice was established by the intratracheal administration of LPS, and the underlying mechanisms were assessed by detecting changes in histopathological and inflammatory markers and Western blotting in lung tissues.Results: Emodin inhibited the inflammatory factor production and oxidative stress in RAW264.7 cells, and prolonged the survival of zebrafish larvae after LPS stimulation. Emodin suppressed the expression levels of phosphorylated JNK at Thr183/tyr182 and phosphorylated Nur77 at Ser351 and c-Jun, and increased the expression level of Nur77 in LPS-stimulated RAW264.7 cells, while these regulatory effects of emodin on Nur77/c-Jun were counteracted by JNK activators. The overexpression of JNK dampened the emodin-mediated increase in Nur77 luciferase activity and Nur77 expression. Moreover, the inhibitory effect of emodin on c-Jun can be attenuated by Nur77 siRNA. Furthermore, emodin alleviated LPS-induced ALI in mice through the regulation of the JNK/Nur77/c-Jun pathway.Conclusions: Emodin protects against LPS-induced ALI through regulation on JNK/Nur77/c-Jun signaling. Our results indicate the potential of emodin in the treatment of ALI.

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“…A previous report linking naturally occurring starch with a slow absorption rate suggested that many individuals are only partially capable of digesting plant starch, and high starch contents in herbal decoctions may lead to adverse drug reactions such as bloating, indigestion, and acid reflux. 9 FDY2004 is a processed formulation derived from Daehwangmokdanpi-tang (named Dahuangmudani-tang in China), which comprises Rheum palmatum, 10 Paeonia suffruticosa, 11,12 and Prunus davidiana 13 ; it is known to be effective against pancreatitis 14,15 and to have anti-inflammatory and antiproliferative effects in cancer cells through downregulation of matrix metallopeptidase 2 (a cancer cell metastasis factor), 16 interleukin -1β, and tumor necrosis factor-α (an inflammatory gene). 17 Therefore, it is expected to have an antiproliferative effect in other cancer cells.…”

mentioning

confidence: 99%

Influence of Decoction Duration of FDY2004 on Its Physicochemical Components and Antioxidant and Antiproliferative Activities

Lee¹,

Lee

Kang

et al. 2020

Natural Product Communications

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FDY2004 (Medicinal herbs: Rheum palmatum, Paeonia suffruticosa Andrews, and Prunus davidiana), an herbal drug composition with an antiproliferative effect, is prepared by boiling, which is the most common herbal extraction method in traditional Korean medicine. Several parameters are considered in the process, including herb-to-solvent ratio, extraction temperature and pressure, and total decoction time. The aim of this study was to examine the physicochemical changes, index compound analysis results, antioxidant activity, and antiproliferative activity of FDY2004 according to the decoction duration to establish the conditions that ensure efficacy while minimizing side effects. Different samples of FDY2004 were obtained by decocting for 30, 60, 90, 120, 180, and 240 minutes. Each sample was evaluated for hydrogen ion concentration (pH), total soluble solid content (TSSC), index compound profiles, and antioxidative and antiproliferative activity. pH was found to decrease, while TSSC increased with an increase in decoction duration. Index compound contents for FDY2004 (aloe emodin, emodin, rhein, chrysophanol, physcion, and sennoside A for R. palmatum, paeonol for P. suffruticosa Andrews, and amygdalin for P. davidiana) increased when the decoction duration was 120 minutes or more, while the content of sennoside A did not increase. The total d-glucose amount increased with an increase in boiling duration. Antioxidant activity of FDY2004 increased when the decoction duration was 120 minutes or more, and the antiproliferative activity of FDY2004 was concentration dependent. The decoction duration for FDY2004 needs to be carefully determined so as to maintain efficacy while reducing side effects related to digestive absorption.

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The Use of Rheum Palmatum L. In the Treatment of Acute Respiratory Distress Syndrome: A Meta-Analysis of Randomized, Controlled Trials

Abstract: Background: Chinese medicine theory shows that "lung being connected with large intestine", and the modern western

Cited by 6 publications

References 5 publications

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway

Influence of Decoction Duration of FDY2004 on Its Physicochemical Components and Antioxidant and Antiproliferative Activities

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