The Use of Ritodrine in the Treatment of Premature Labour

Rénaud, R; Irrmann, M; Gandar, R; Flynn, Mark J.

doi:10.1097/00006254-197410000-00002

Cited by 2 publications

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“…1 and 7.5 respectively. An open study of ritodrine by Renaud et al (1974) recorded mean scores of 7.3 and 7.7.…”

Section: Discussionmentioning

confidence: 99%

Ritodrine in the treatment of preterm labour: a study of 213 patients

Downey¹,

Martin²

1983

BJOG

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In a study of 213 patients with diagnosed, uncomplicated preterm labour up to 33 weeks gestation, intravenous followed by oral ritodrine (Yutopar) was found to be an effective treatment. Success rate was related to Bishop score at commencement of therapy, the mean time to delivery being 36.9 days. It was 2 5 6 days in 26.5% of patients and 3 2 days in 9 1%. Relapse rate was low if infusion was followed by an adequate

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“…1 and 7.5 respectively. An open study of ritodrine by Renaud et al (1974) recorded mean scores of 7.3 and 7.7.…”

Section: Discussionmentioning

confidence: 99%

Ritodrine in the treatment of preterm labour: a study of 213 patients

Downey¹,

Martin²

1983

BJOG

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“…Selective fi2-adrenoceptor agonists have found an increasing use in obstetrics to prevent premature labour [17,25,27,29,31,34]. While the cardiovascular side effects of this therapy have received attention [27,29] the possible metabolic side effects have not been extensively studied.…”

mentioning

confidence: 99%

Actions of salbutamol in late pregnancy: Plasma cyclic AMP, insulin and C-peptide, carbohydrate and lipid metabolites in diabetic and non-diabetic women

et al. 1978

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Salbutamol was administered intravenously in dose increasing from 3.75 to 22.5 microgram/min to 5 non-diabetic and 7 diabetic women in the last trimester of pregnancy. In diabetic as well as non-diabetic women the diastolic blood pressure fell progressively with increasing doses, and the systolic BP and heart rate increased at doses above 7.5 microgram/min. The effect of fetal heart rate was less pronounced than the effect on maternal heart rate. Cyclic AMP levels in plasma were similar in non-diabetic and diabetic women before salbutamol. Twenty min following 3.75 microgram/min a significant increase was seen in both groups. The peak increase (3-5 fold) was higher in the diabetic than in the non-diabetic women. Plasma insulin and C-peptide levels rose in a dose-dependent manner in the non-diabetic and four of the diabetic women. However, in three of the diabetic women the insulin level was unaffected by salbutamol and C-peptide was almost undetectable. Plasma concentrations of glucose, glycerol, NEFA and 3-HB were higher in the diabetics than in the non-diabetics before salbutamol and the elevations induced by salbutamol were also significantly larger in the diabetic women. The present data show that salbutamol in doses employed clinically may cause pronounced metabolic effects, especially in diabetic women, and it is suggested that when intravenous infusion of salbutamol is given to pregnant diabetic women not only cardiovascular but also some metabolic variable such as glucose should be carefully monitored.

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The Use of Ritodrine in the Treatment of Premature Labour

Cited by 2 publications

References 0 publications

Ritodrine in the treatment of preterm labour: a study of 213 patients

Ritodrine in the treatment of preterm labour: a study of 213 patients

Actions of salbutamol in late pregnancy: Plasma cyclic AMP, insulin and C-peptide, carbohydrate and lipid metabolites in diabetic and non-diabetic women

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